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Publikationer i urvalet

16 träffar

Bibliografisk träff 2018-11-02

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.

Tanis SP, Colca JR, Parker TT, Artman GD, Larsen SD, McDonald WG, Gadwood RC, Kletzien RF, Zeller JB, Lee PH, Adams WJ.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2018.10.033

Bibliografisk träff 2018-02-27

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.

Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, Jacquier E, Gauthier E, Lepais V, Chatar M, Ferry S, Thourigny A, Guillier F, Llacer J, Amaudrut J, Dodey P, Lacombe O, Masson P, Montalbetti C, Wettstein G, Luccarini JM, Legendre C, Junien JL, Broqua P.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b01285

Bibliografisk träff 2017-06-12

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.06.006

Bibliografisk träff 2015-02-04

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Zhang H, Ding CZ, Lai Z, Chen SS, Devasthale P, Herpin T, Morton G, Qu F, Ryono D, Smirk R, Wang W, Wu S, Ye XX, Li YX, Apedo A, Farrelly D, Wang T, Gu L, Morgan N, Flynn N, Chu C, Kunselman L, Lippy J, Locke K, O'Malley K, Harrity T, Cap M, Zhang L, Hosagrahara V, Kadiyala P, Xu C, Doweyko AM, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2015.01.066

Bibliografisk träff 2012-10-02

Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).

Shibata Y, Kagechika K, Yamaguchi M, Kubo H, Usui H.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.09.092

Bibliografisk träff 2010-09-28

Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.

Zhang D, Raghavan N, Wang L, Xue Y, Obermeier M, Chen S, Tao S, Zhang H, Cheng PT, Li W, Ramanathan R, Yang Z, Humphreys WG.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.035048

Bibliografisk träff 2009-01-15

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2009.01.030

Bibliografisk träff 2008-10-17

Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety.

Pingali H, Jain M, Shah S, Patil P, Makadia P, Zaware P, Sairam KV, Jamili J, Goel A, Patel M, Patel P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.10.062

Bibliografisk träff 2008-10-01

Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.

Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm8003416

Bibliografisk träff 2008-08-12

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.

Kim E, Park CS, Han T, Bae MH, Chong W, Lee CH, Shin YA, Ahn BN, Kim MK, Shin CY, Son MH, Kim JK, Moon HS, Shim HJ, Kim EJ, Kim SH, Lim JI, Lee CH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.08.020

Bibliografisk träff 2008-05-06

Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.

Ye XY, Li YX, Farrelly D, Flynn N, Gu L, Locke KT, Lippy J, O'Malley K, Twamley C, Zhang L, Ryono DE, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.05.014

Bibliografisk träff 2008-02-07

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

Wang W, Devasthale P, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Kunselman L, Morgan N, Ponticiello R, Zebo R, Zhang L, Locke K, Lippy J, O'Malley K, Hosagrahara V, Zhang L, Kadiyala P, Chang C, Muckelbauer J, Doweyko AM, Zahler R, Ryono D, Hariharan N, Cheng PT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.01.126

Bibliografisk träff 2007-01-25

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.01.060

Bibliografisk träff 2006-10-24

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos · comparative study; clinical trial; journal article · DOI 10.1124/dmd.106.012450

Bibliografisk träff 2005-03-01

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.

J Med Chem · journal article · DOI 10.1021/jm0496436

Bibliografisk träff 2004-08-01

Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

Henke BR.

J Med Chem · review; journal article · DOI 10.1021/jm030631e