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Publikationer i urvalet

21 träffar

Bibliografisk träff 2021-11-16

The Sigma-2 Receptor/TMEM97 Agonist PB28 Suppresses Cell Proliferation and Invasion by Regulating the PI3K-AKT-mTOR Signalling Pathway in Renal Cancer.

Zhan B, Zhang Z, Piao C, Dong X, Du Y, Kong C, Jiang Y.

J Cell Mol Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/jcmm.17047

Bibliografisk träff 2020-12-07

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.

Abate C, Niso M, Abatematteo FS, Contino M, Colabufo NA, Berardi F.

Front Pharmacol · review-article; review; journal article · DOI 10.3389/fphar.2020.589810

Bibliografisk träff 2020-08-14

Why PB28 Could Be a Covid 2019 Game Changer?

Colabufo NA, Leopoldo M, Ferorelli S, Abate C, Contino M, Perrone MG, Niso M, Perrone R, Berardi F.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.0c00271

Bibliografisk träff 2017-11-09

Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.

Sun YT, Wang GF, Yang YQ, Jin F, Wang Y, Xie XY, Mach RH, Huang YS.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.11.016

Bibliografisk träff 2017-07-17

Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel σ<sub>1</sub> receptor ligands.

Fanter L, Müller C, Schepmann D, Bracher F, Wünsch B.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.07.027

Bibliografisk träff 2017-01-13

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

Pati ML, Hornick JR, Niso M, Berardi F, Spitzer D, Abate C, Hawkins W.

BMC Cancer · research-article; journal article · DOI 10.1186/s12885-016-3040-4

Bibliografisk träff 2015-01-06

Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.

Selivanova SV, Toscano A, Abate C, Berardi F, Müller A, Krämer SD, Schibli R, Ametamey SM.

Nucl Med Biol · journal article · DOI 10.1016/j.nucmedbio.2014.12.018

Bibliografisk träff 2014-04-14

Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.

Abate C, Niso M, Marottoli R, Riganti C, Ghigo D, Ferorelli S, Ossato G, Perrone R, Lacivita E, Lamb DC, Berardi F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm401874n

Bibliografisk träff 2013-02-08

Evidences for the involvement of sigma receptors in antidepressant like effect of quetiapine in mice.

Kotagale NR, Mendhi SM, Aglawe MM, Umekar MJ, Taksande BG.

Eur J Pharmacol · journal article · DOI 10.1016/j.ejphar.2013.01.045

Bibliografisk träff 2012-08-13

2-Aminopyridine derivatives as potential σ(2) receptor antagonists.

Abate C, Ferorelli S, Niso M, Lovicario C, Infantino V, Convertini P, Perrone R, Berardi F.

ChemMedChem · journal article · DOI 10.1002/cmdc.201200246

Bibliografisk träff 2011-07-20

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.

Abate C, Hornick JR, Spitzer D, Hawkins WG, Niso M, Perrone R, Berardi F.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm200591t

Bibliografisk träff 2011-05-30

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.

Abate C, Ferorelli S, Contino M, Marottoli R, Colabufo NA, Perrone R, Berardi F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2011.05.057

Bibliografisk träff 2011-01-13

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.

Abate C, Niso M, Lacivita E, Mosier PD, Toscano A, Perrone R.

J Med Chem · journal article · DOI 10.1021/jm1013133

Bibliografisk träff 2010-02-01

Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer.

Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA.

ChemMedChem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1002/cmdc.200900402

Bibliografisk träff 2009-12-01

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R.

J Med Chem · journal article · DOI 10.1021/jm9007505

Bibliografisk träff 2009-09-01

1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review.

Berardi F, Abate C, Ferorelli S, Colabufo NA, Perrone R.

Cent Nerv Syst Agents Med Chem · review; journal article · DOI 10.2174/1871524910909030205

Bibliografisk träff 2009-01-01

Role of active drug transporters in refractory multiple myeloma.

Tucci M, Quatraro C, Dammacco F, Silvestris F.

Curr Top Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.2174/156802609787521625

Bibliografisk träff 2007-12-25

Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization.

Colabufo NA, Abate C, Contino M, Inglese C, Ferorelli S, Berardi F, Perrone R.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.12.056

Bibliografisk träff 2006-07-01

Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.

Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A.

Mol Cancer Ther · research support, non-u.s. gov't; journal article · DOI 10.1158/1535-7163.mct-05-0402

Bibliografisk träff 2006-05-09

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells.

Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA.

Cell Calcium · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ceca.2006.03.004

Bibliografisk träff 2004-07-31

Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.

Colabufo NA, Berardi F, Contino M, Niso M, Abate C, Perrone R, Tortorella V.

Naunyn Schmiedebergs Arch Pharmacol · comparative study; journal article · DOI 10.1007/s00210-004-0961-2