Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling.
Visa A, Alza L, Cantí C, Herreros J.
Biomed Pharmacother · journal article · DOI 10.1016/j.biopha.2022.112881 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
15 träffarExpression of T-Type Voltage-Gated Calcium Channel in the Cilia of Human Nasal Epithelial Cells.
Nguyen TN, Suzuki H, Baba R, Yoshida Y, Ohkubo JI, Wakasugi T, Kitamura T.
Int Arch Allergy Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1159/000521765Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach.
Lu Y, Li M, Lee GY, Zhao N, Chen Z, Edwards A, Zhang K.
Pharmacol Res Perspect · research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/prp2.783Vascular Kv7 channels control intracellular Ca<sup>2+</sup> dynamics in smooth muscle.
Tsai YM, Jones F, Mullen P, Porter KE, Steele D, Peers C, Gamper N.
Cell Calcium · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.ceca.2020.102283Progesterone induces the release of bull spermatozoa from oviductal epithelial cells.
Romero-Aguirregomezcorta J, Cronin S, Donnellan E, Fair S.
Reprod Fertil Dev · journal article · DOI 10.1071/rd18316NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.
Matsuda S, Nishikawa H, Fukatsu A, Kurokawa Y, Tsubota M, Sekiguchi F, Tokuyama S, Kawabata A.
J Pharmacol Sci · journal article · DOI 10.1016/j.jphs.2019.02.002Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels.
Sairaman A, Cardoso FC, Bispat A, Lewis RJ, Duggan PJ, Tuck KL.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.03.031T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.
Huang W, Lu C, Wu Y, Ouyang S, Chen Y.
J Exp Clin Cancer Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s13046-015-0171-4Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life.
Fernández-Morales JC, Fernando Padín J, Vestring S, Musial DC, de Diego AM, García AG.
Eur J Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejphar.2015.01.025NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction.
Kim KH, Kim D, Park JY, Jung HJ, Cho YH, Kim HK, Han J, Choi KY, Kwon HJ.
J Mol Med (Berl) · research support, non-u.s. gov't; journal article · DOI 10.1007/s00109-014-1235-1Ca2+ channel inhibitor NNC 55-0396 inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
Son YK, Hong DH, Li H, Kim DJ, Na SH, Park H, Jung WK, Choi IW, Park WS.
J Pharmacol Sci · research support, non-u.s. gov't; journal article · DOI 10.1254/jphs.14054fpNeurotoxicity induced by bupivacaine via T-type calcium channels in SH-SY5Y cells.
Wen X, Xu S, Liu H, Zhang Q, Liang H, Yang C, Wang H.
PLoS One · retracted publication; research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0062942Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
Quesada A, Bui PH, Homanics GE, Hankinson O, Handforth A.
Eur J Pharmacol · comparative study; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejphar.2011.01.004Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396.
Li M, Hansen JB, Huang L, Keyser BM, Taylor JT.
Cardiovasc Drug Rev · comparative study; journal article · DOI 10.1111/j.1527-3466.2005.tb00164.xNNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels.
Huang L, Keyser BM, Tagmose TM, Hansen JB, Taylor JT, Zhuang H, Zhang M, Ragsdale DS, Li M.
J Pharmacol Exp Ther · research support, non-u.s. gov't; journal article · DOI 10.1124/jpet.103.060814