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Publikationer i urvalet

20 träffar

Bibliografisk träff 2023-10-20

Identification of novel glucocerebrosidase chaperones by unexpected skeletal rearrangement reaction.

Takeda K, Watanabe T, Smith JR, Vesey D, Tiberghien N, Lewis S, Powney B, Schapira AHV, Hoshikawa T, Takle AK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2023.129531

Bibliografisk träff 2023-01-12

Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones.

Hoshikawa T, Watanabe T, Kotake M, Tiberghien N, Woo CK, Lewis S, Briston T, Koglin M, Staddon JM, Powney B, Schapira AHV, Takle AK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2023.129130

Bibliografisk träff 2022-05-29

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.

Wang JZ, Shimadate Y, Kise M, Kato A, Jia YM, Li YX, Fleet GWJ, Yu CY.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114499

Bibliografisk träff 2019-01-15

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase.

Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b01294

Bibliografisk träff 2018-09-21

4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations.

Front S, Almeida S, Zoete V, Charollais-Thoenig J, Gallienne E, Marmy C, Pilloud V, Marti R, Wood T, Martin OR, Demotz S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.09.023

Bibliografisk träff 2017-10-10

Orthoester functionalized <i>N</i>-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase.

Sevšek A, Sastre Toraño J, Quarles van Ufford L, Moret EE, Pieters RJ, Martin NI.

Medchemcomm · research-article; journal article · DOI 10.1039/c7md00480j

Bibliografisk träff 2016-09-06

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators.

Zheng J, Chen L, Schwake M, Silverman RB, Krainc D.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.6b00930

Bibliografisk träff 2014-03-12

Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.

Kato A, Nakagome I, Nakagawa S, Koike Y, Nash RJ, Adachi I, Hirono S.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.02.057

Bibliografisk träff 2013-03-11

Pharmacological chaperones as therapeutics for lysosomal storage diseases.

Boyd RE, Lee G, Rybczynski P, Benjamin ER, Khanna R, Wustman BA, Valenzano KJ.

J Med Chem · review; journal article · DOI 10.1021/jm301557k

Bibliografisk träff 2011-10-24

Non-iminosugar glucocerebrosidase small molecule chaperones.

Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E.

Medchemcomm · research-article; journal article · DOI 10.1039/c1md00200g

Bibliografisk träff 2011-08-04

Synthesis of new six- and seven-membered 1-N-iminosugars as promising glycosidase inhibitors.

Jabgunde AM, Kalamkar NB, Chavan ST, Sabharwal SG, Dhavale DD.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2011.07.059

Bibliografisk träff 2011-07-22

Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.

Burland PA, Osborn HM, Turkson A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.07.019

Bibliografisk träff 2011-04-13

Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.

Kato A, Miyauchi S, Kato N, Nash RJ, Yoshimura Y, Nakagome I, Hirono S, Takahata H, Adachi I.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2011.04.011

Bibliografisk träff 2011-01-20

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP.

J Med Chem · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm1008902

Bibliografisk träff 2011-01-08

Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.

Rasmussen TS, Allman S, Twigg G, Butters TD, Jensen HH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.12.106

Bibliografisk träff 2008-06-18

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.

Kuriyama C, Kamiyama O, Ikeda K, Sanae F, Kato A, Adachi I, Imahori T, Takahata H, Okamoto T, Asano N.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2008.06.026

Bibliografisk träff 2008-05-01

Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.

Tailford LE, Offen WA, Smith NL, Dumon C, Morland C, Gratien J, Heck MP, Stick RV, Blériot Y, Vasella A, Gilbert HJ, Davies GJ.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio.81

Bibliografisk träff 2006-12-24

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.

Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA.

Nat Chem Biol · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1038/nchembio850

Bibliografisk träff 2006-09-01

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

Oikonomakos NG, Tiraidis C, Leonidas DD, Zographos SE, Kristiansen M, Jessen CU, Nørskov-Lauritsen L, Agius L.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm060496g

Bibliografisk träff 2006-02-14

Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols.

Greimel P, Häusler H, Lundt I, Rupitz K, Stütz AE, Tarling CA, Withers SG, Wrodnigg TM.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2006.01.095