The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Gangjee A, Jain HD, Queener SF, Kisliuk RL.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800244v