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Publikationer i urvalet

11 träffar

Bibliografisk träff 2023-10-01

Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.

Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A.

Blood · research-article; journal article · DOI 10.1182/blood.2023020441

Bibliografisk träff 2023-06-22

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.

Renna SA, Zhao X, Kunapuli SP, Ma P, Holinstat M, Boxer MB, Maloney DJ, Michael JV, McKenzie SE.

Arterioscler Thromb Vasc Biol · research support, non-u.s. gov't; journal article · DOI 10.1161/atvbaha.123.319434

Bibliografisk träff 2022-02-23

ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets.

Shpakova V, Rukoyatkina N, Al Arawe N, Prilepskaya A, Kharazova A, Sharina I, Gambaryan S, Martin E.

J Pharmacol Exp Ther · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/jpet.121.000973

Bibliografisk träff 2021-08-04

Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.

Tsai WC, Aleem AM, Tena J, Rivera-Velazquez M, Brah HS, Tripathi S, D'silva M, Nadler JL, Kalyanaraman C, Jacobson MP, Holman T.

Bioorg Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2021.116347

Bibliografisk träff 2021-07-22

12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.

Kulkarni A, Pineros AR, Walsh MA, Casimiro I, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM.

JCI Insight · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1172/jci.insight.147812

Bibliografisk träff 2020-12-04

Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice.

He H, Adili R, Liu L, Hong K, Holinstat M, Schwendeman A.

Sci Adv · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/sciadv.abd0130

Bibliografisk träff 2020-11-01

[Antagonistic effect of 12-lipoxygenase inhibitor ML355 on lipopolysaccharide induced inflammatory response in mice].

Wang X, Tang W, Chen T, Luo L, Liang H.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · journal article · DOI 10.3760/cma.j.cn121430-20200429-00349

Bibliografisk träff 2020-08-25

Pharmacological characterization of the biosynthesis of prostanoids and hydroxyeicosatetraenoic acids in human whole blood and platelets by targeted chiral lipidomics analysis.

Tacconelli S, Fullone R, Dovizio M, Pizzicoli G, Marschler S, Bruno A, Zucchelli M, Contursi A, Ballerini P, Patrignani P.

Biochim Biophys Acta Mol Cell Biol Lipids · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbalip.2020.158804

Bibliografisk träff 2017-08-03

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.

Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M.

Arterioscler Thromb Vasc Biol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/atvbaha.117.309868

Bibliografisk träff 2017-08-01

12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.

Ma K, Xiao A, Park SH, Glenn L, Jackson L, Barot T, Weaver JR, Taylor-Fishwick DA, Luci DK, Maloney DJ, Mirmira RG, Imai Y, Nadler JL.

J Clin Endocrinol Metab · research-article; journal article · DOI 10.1210/jc.2017-00267

Bibliografisk träff 2014-09-18

Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase

Luci D, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Schultz L, Holinstat M, Nadler J, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ.

Tidskrift saknas · review