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Publikationer i urvalet

25 träffar

Bibliografisk träff 2023-11-06

ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors.

Terlizzi C, De Rosa V, Iommelli F, Pezone A, Altobelli GG, Maddalena M, Dimitrov J, De Rosa C, Della Corte CM, Avvedimento VE, Del Vecchio S.

Cancer Metab · research-article; journal article · DOI 10.1186/s40170-023-00320-4

Bibliografisk träff 2023-09-26

An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and connectivity mapping.

Hu Y, Zhang X, Li Q, Zhou Q, Fang D, Lu Y.

Comput Struct Biotechnol J · research-article; journal article · DOI 10.1016/j.csbj.2023.09.030

Bibliografisk träff 2023-06-15

Nerve Injury-Induced γH2AX Reduction in Primary Sensory Neurons Is Involved in Neuropathic Pain Processing.

Zhang Y, Gong H, Wang JS, Li MN, Cao DL, Gu J, Zhao LX, Zhang XD, Deng YT, Dong FL, Gao YJ, Sun WX, Jiang BC.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms241210148

Bibliografisk träff 2023-04-08

Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice.

Li H, Li X, Kong Y, Sun W.

Immunobiology · journal article · DOI 10.1016/j.imbio.2023.152383

Bibliografisk träff 2023-03-21

Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation.

Hwang M, Jun DW, Song BR, Shim H, Lee CH, Kim S.

Biomol Ther (Seoul) · research-article; journal article · DOI 10.4062/biomolther.2023.003

Bibliografisk träff 2023-02-25

A Triphenylphosphonium-Functionalized Delivery System for an ATM Kinase Inhibitor That Ameliorates Doxorubicin Resistance in Breast Carcinoma Mammospheres.

Stagni V, Kaminari A, Contadini C, Barilà D, Sessa RL, Sideratou Z, Vlahopoulos SA, Tsiourvas D.

Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers15051474

Bibliografisk träff 2022-12-13

ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice.

Li M, Yang Z, Song Z, Bo C, Wang S, Jia Q.

Toxicology · research support, non-u.s. gov't; journal article · DOI 10.1016/j.tox.2022.153397

Bibliografisk träff 2022-10-31

Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection.

Erickson JR, Kalejta RF, Friesen PD.

J Virol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/jvi.01269-22

Bibliografisk träff 2022-09-15

Combined ataxia telangiectasia mutated and DNA-dependent protein kinase inhibition radiosensitizes Madin-Darby canine kidney cells.

Koike M, Yutoku Y, Koike A.

J Vet Med Sci · research-article; journal article · DOI 10.1292/jvms.22-0061

Bibliografisk träff 2022-01-01

Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer.

Liu K, Chen Y, Shi XB, Xing ZH, He ZJ, Wang ST, Li YC, Liu WJ, Zhang PW, Yu ZZ, Mo XM, Shi XY, Chen ZS, Shi Z.

Recent Pat Anticancer Drug Discov · journal article · DOI 10.2174/1574892817666220112100036

Bibliografisk träff 2021-11-16

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation.

Shikata M, Toyooka T, Komaki Y, Ibuki Y.

Chem Res Toxicol · journal article · DOI 10.1021/acs.chemrestox.1c00287

Bibliografisk träff 2021-09-23

Molecular basis of human ATM kinase inhibition.

Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E, Hopfner KP.

Nat Struct Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/s41594-021-00654-x

Bibliografisk träff 2021-04-01

ATM inhibitor KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake in aggressive cancer cells with sustained activation of Akt.

Harris BRE, Zhang Y, Tao J, Shen R, Zhao X, Cleary MP, Wang T, Yang DQ.

FASEB J · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1096/fj.202001415rr

Bibliografisk träff 2021-03-01

The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells.

Moolmuang B, Ruchirawat M.

J Pharm Pharmacol · journal article · DOI 10.1093/jpp/rgaa050

Bibliografisk träff 2020-12-01

Decreased activation of ataxia telangiectasia mutated (ATM) in monocytes from patients with systemic sclerosis.

Sakata K, Yasuoka H, Yoshimoto K, Takeuchi T.

Rheumatology (Oxford) · journal article · DOI 10.1093/rheumatology/keaa312

Bibliografisk träff 2019-02-13

Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-<i>Toxoplasma gondii</i> Agent.

Munera López J, Ganuza A, Bogado SS, Muñoz D, Ruiz DM, Sullivan WJ, Vanagas L, Angel SO.

Front Cell Infect Microbiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.3389/fcimb.2019.00026

Bibliografisk träff 2017-04-09

Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells.

Liu J, Liu Y, Meng L, Ji B, Yang D.

Int J Med Sci · research-article; journal article · DOI 10.7150/ijms.19033

Bibliografisk träff 2017-03-21

The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.

Chwastek J, Jantas D, Lasoń W.

Int J Biochem Cell Biol · journal article · DOI 10.1016/j.biocel.2017.03.015

Bibliografisk träff 2015-11-17

Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.

Tian X, Lara H, Wagner KT, Saripalli S, Hyder SN, Foote M, Sethi M, Wang E, Caster JM, Zhang L, Wang AZ.

Nanoscale · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1039/c5nr05869d

Bibliografisk träff 2015-02-06

The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.

Zhang T, Shen Y, Chen Y, Hsieh JT, Kong Z.

Int J Radiat Biol · research support, non-u.s. gov't; journal article · DOI 10.3109/09553002.2015.1001531

Bibliografisk träff 2012-11-21

Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.

Zakikhani M, Bazile M, Hashemi S, Javeshghani S, Avizonis D, St Pierre J, Pollak MN.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0049513

Bibliografisk träff 2012-10-03

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells.

Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN.

J Neurooncol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s11060-012-0979-0

Bibliografisk träff 2012-06-22

Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.

Khalil HS, Tummala H, Hupp TR, Zhelev N.

Exp Biol Med (Maywood) · research support, non-u.s. gov't; journal article · DOI 10.1258/ebm.2012.011378

Bibliografisk träff 2010-01-06

The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

Li Y, Yang DQ.

Mol Cancer Ther · research support, non-u.s. gov't; journal article · DOI 10.1158/1535-7163.mct-08-1189

Bibliografisk träff 2004-12-01

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC.

Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/0008-5472.can-04-2727