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Publikationer i urvalet

11 träffar

Bibliografisk träff 2022-05-25

Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL.

Yuan Y, Du L, Tan R, Yu Y, Jiang J, Yao A, Luo J, Tang R, Xiao Y, Sun H.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00083

Bibliografisk träff 2022-03-18

Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.

Khirsariya P, Pospíšil P, Maier L, Boudný M, Babáš M, Kroutil O, Mráz M, Vácha R, Paruch K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c02228

Bibliografisk träff 2021-03-10

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.

Dominici C, Sgarioto N, Yu Z, Sesma-Sanz L, Masson JY, Richard S, Raynal NJ.

Clin Epigenetics · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s13148-021-01037-1

Bibliografisk träff 2019-12-04

New Potent DOT1L Inhibitors for <i>in Vivo</i> Evaluation in Mouse.

Stauffer F, Weiss A, Scheufler C, Möbitz H, Ragot C, Beyer KS, Calkins K, Guthy D, Kiffe M, Van Eerdenbrugh B, Tiedt R, Gaul C.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00452

Bibliografisk träff 2019-06-26

Why Some Targets Benefit from beyond Rule of Five Drugs.

Egbert M, Whitty A, Keserű GM, Vajda S.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b01732

Bibliografisk träff 2018-08-31

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling.

Ishiguro K, Kitajima H, Niinuma T, Ishida T, Maruyama R, Ikeda H, Hayashi T, Sasaki H, Wakasugi H, Nishiyama K, Shindo T, Yamamoto E, Kai M, Sasaki Y, Tokino T, Nakase H, Suzuki H.

Haematologica · research support, non-u.s. gov't; research-article; journal article · DOI 10.3324/haematol.2018.191262

Bibliografisk träff 2018-01-26

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway.

Wang L, Dong X, Ren Y, Luo J, Liu P, Su D, Yang X.

Cell Death Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41419-017-0120-6

Bibliografisk träff 2017-10-10

Preparation of 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives and their activity against DOT1L.

Liu T, Xie W, Li C, Ren H, Mao Y, Chen G, Cheng M, Zhao D, Shen J, Li J, Zhou Y, Xiong B, Chen YL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.10.019

Bibliografisk träff 2017-02-14

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.

Möbitz H, Machauer R, Holzer P, Vaupel A, Stauffer F, Ragot C, Caravatti G, Scheufler C, Fernandez C, Hommel U, Tiedt R, Beyer KS, Chen C, Zhu H, Gaul C.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.6b00519

Bibliografisk träff 2014-12-02

Selective inhibitors of protein methyltransferases.

Kaniskan HÜ, Konze KD, Jin J.

J Med Chem · research support, non-u.s. gov't; review-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm501234a

Bibliografisk träff 2013-08-14

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

Anglin JL, Song Y.

J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm4007752