NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model.
Lee M, Ko YK, Jang S, Gil CH, Eun KM, Zhang YL, Cho SW, Kim DW, Kim HJ, Rhee CS.
Asian Pac J Allergy Immunol · journal article · DOI 10.12932/ap-301223-1756 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för MCC950. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
31 träffarStructural Insight into the Binding Pattern and Interaction Mechanism of Antagonist MCC950 and Agonist BMS986299 with NLRP3 by Molecular Dynamics Simulation.
Zhang R, Xiong X, Min Z.
Curr Comput Aided Drug Des · journal article · DOI 10.2174/0115734099313497240514072445MCC950 promotes diabetic wound healing through modulating macrophage polarization in an MDSC-dependent manner.
Yan W, Ni T, Zhang Q, Sun X, Xu Z, Li X, Yi M, Wang Y, Zhang H, Shi J, Zhu Z.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2024.112983Shikonin from <i>lithospermum erythrorhizon</i> induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Zeng F, Lai Y, Huang Y, Zhu F, Gao J, Chen Z, Zeng L, Feng M, Qiu P, Yuan S, Deng G.
Ann Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1080/07853890.2024.2394584MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions.
Zheng Y, Zhang X, Wang Z, Zhang R, Wei H, Yan X, Jiang X, Yang L.
Arch Pharm (Weinheim) · review; journal article · DOI 10.1002/ardp.202400459Development of CRID3-Based Anti-inflammatory Agents to Ameliorate Chronic Hypoxia-Induced Memory Impairment in Zebrafish Models.
Soren K, Bollikanda RK, Das T, Patel S, Gnaneshwari K, Malakar P, Kumar A, Kantevari S, Chakravarty S.
ACS Chem Neurosci · research support, non-u.s. gov't; journal article · DOI 10.1021/acschemneuro.4c00154Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis.
Liu Y, Jiang Z, Zhang L, Tian W, Lin A, Li M.
Reprod Biomed Online · journal article · DOI 10.1016/j.rbmo.2024.104319Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia.
Gao S, Li N, Lin Z, Zhong Y, Wang Y, Shen X.
FASEB J · research support, non-u.s. gov't; journal article · DOI 10.1096/fj.202301922rrPyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia.
Ye X, Lin ZJ, Hong GH, Wang ZM, Dou RT, Lin JY, Xie JH, Shen YW.
Exp Cell Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.yexcr.2024.114061Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency.
Vande Walle L, Said M, Paerewijck O, Bertoni A, Gattorno M, Linclau B, Lamkanfi M.
Life Sci Alliance · research support, non-u.s. gov't; research-article; journal article · DOI 10.26508/lsa.202402644Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3.
Zhao H, Kumar P, Sobreira TJP, Smith M, Novick S, Johansson A, Luchniak A, Zhang A, Woollard KJ, Larsson N, Kawatkar A.
ACS Chem Biol · journal article · DOI 10.1021/acschembio.3c00777MCC950 attenuates plasma cell mastitis in an MDSC-dependent manner.
Sun X, Hou J, Ni T, Xu Z, Yan W, Kong L, Zhang Q.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2024.111803MCC950 Attenuates Microglial NLRP3-Mediated Chronic Neuroinflammation and Memory Impairment in a Rat Model of Repeated Low-Level Blast Exposure.
Ravula AR, Murray KE, Rao KVR, Pfister BJ, Citron BA, Chandra N.
J Neurotrauma · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1089/neu.2023.0444Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome in systemic lupus erythematosus.
Wu X, Yang J, Wu J, Yang X.
Biomed Pharmacother · review; journal article · DOI 10.1016/j.biopha.2024.116261Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway.
Guo F, Han X, You Y, Xu SJ, Zhang YH, Chen YY, Xin GJ, Liu ZX, Ren JG, Cao C, Li LM, Fu JH.
Chin J Integr Med · journal article · DOI 10.1007/s11655-023-3716-yMCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise.
Yan X, Fu P, Zhang Y, Ling D, Reynolds L, Hua W, Wang Z, Ma F, Li B, Yu J, Liu Y, Gong L, Zhang E.
Molecules · research-article; journal article · DOI 10.3390/molecules29030712Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive.
Sabra MS, Hemida FK, Allam EAH.
BMC Nephrol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12882-023-03427-4Quercetin suppresses ovariectomy-induced osteoporosis in rat mandibles by regulating autophagy and the NLRP3 pathway.
Xiong Y, Huang CW, Shi C, Peng L, Cheng YT, Hong W, Liao J.
Exp Biol Med (Maywood) · research support, non-u.s. gov't; research-article; journal article · DOI 10.1177/15353702231211977MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy.
Hong Y, Wei C, Fu M, Li X, Zhang H, Yao B.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2023.111236MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease.
Naeem A, Prakash R, Kumari N, Ali Khan M, Quaiyoom Khan A, Uddin S, Verma S, Ab Robertson A, Boltze J, Shadab Raza S.
Brain Behav Immun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbi.2023.11.031Intraperitoneal Injection of MCC950 Inhibits the Progression of Myopia in Form-Deprivation Myopic Mice.
Chen Z, Xiao K, Long Q.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms242115839NLRP3-inflammasome inhibition by MCC950 attenuates cardiac and pulmonary artery remodelling in heart failure with preserved ejection fraction.
Cheng X, Zhao H, Wen X, Li G, Guo S, Zhang D.
Life Sci · journal article · DOI 10.1016/j.lfs.2023.122185Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice.
Hou B, Yin J, Liu S, Guo J, Zhang B, Zhang Z, Yang L, Tan X, Long Y, Feng S, Zhou J, Wu Y, Wang X, Han S, Wang Z, He X.
Mol Neurobiol · research-article; journal article · DOI 10.1007/s12035-023-03618-yMCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH.
Cao Y, Wang Y, Li X, Yang X, Zeng B, Guo Z.
Brain Res Bull · research support, non-u.s. gov't; journal article · DOI 10.1016/j.brainresbull.2023.110743MCC950 improves lipopolysaccharide‑induced systemic inflammation in mice by relieving pyroptosis in blood neutrophils.
Miao R, Huang J.
Exp Ther Med · research-article; journal article · DOI 10.3892/etm.2023.12117NLRP3 Inflammasome Involved with Viral Replication in Cytopathic NADL BVDV Infection and IFI16 Inflammasome Connected with IL-1β Release in Non-Cytopathic NY-1 BVDV Infection in Bovine Macrophages.
Gallegos-Rodarte C, Escobar-Chavarría O, Cantera-Bravo MM, Sarmiento-Silva RE, Benitez-Guzman A.
Viruses · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/v15071494Selective NLRP3 Inflammasome Inhibitor MCC950 Suppresses Inflammation and Facilitates Healing in Vascular Materials.
Grant AJ, Yang N, Moore MJ, Lam YT, Michael PL, Chan AHP, Santos M, Rnjak-Kovacina J, Tan RP, Wise SG.
Adv Sci (Weinh) · research support, non-u.s. gov't; research-article; journal article · DOI 10.1002/advs.202300521Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3.
Vande Walle L, Lamkanfi M.
Rheumatology (Oxford) · letter; comment; research support, non-u.s. gov't · DOI 10.1093/rheumatology/keac717Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3: Reply.
Weber ANR, Tapia-Abellán A, Liu X, Aróstegui JI, Pelegrín P, Welzel T, Kuemmerle-Deschner JB.
Rheumatology (Oxford) · letter; comment; research support, non-u.s. gov't · DOI 10.1093/rheumatology/keac718Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3.
Weber ANR, Tapia-Abellán A, Liu X, Dickhöfer S, Aróstegui JI, Pelegrín P, Welzel T, Kuemmerle-Deschner JB.
Rheumatology (Oxford) · research support, non-u.s. gov't; journal article · DOI 10.1093/rheumatology/keac273