Small Cell Lung Carcinoma Cells Depend on KIF11 for Survival.
Sakuma Y, Hirai S, Yamaguchi M, Idogawa M.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms25137230 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
16 träffarRequirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan <i>Cryptosporidium parvum</i>.
Wang D, Jiang P, Wu X, Zhang Y, Wang C, Li M, Liu M, Yin J, Zhu G.
mBio · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/mbio.03158-23Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma.
Turaga SM, Vishwakarma V, Hembruff SL, Gibbs BK, Sabu P, Puri RV, Pathak HB, Samuel G, Godwin AK.
Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers15204911A novel antibody-KSP inhibitor conjugate improves KSP inhibitor efficacy in vitro and in vivo.
Li Y, Wang Z, Dong Y, Yu X, Lu J, Jin N, Shang C, Li X, Fan S.
Biomaterials · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biomaterials.2023.122258Kinesin spindle protein inhibitor exacerbates cisplatin-induced hair cell damage.
Tang D, Zheng S, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Chen B, Liu S, He Y.
Arch Biochem Biophys · research support, non-u.s. gov't; journal article · DOI 10.1016/j.abb.2022.109432Epigenetic and Immune-Cell Infiltration Changes in the Tumor Microenvironment in Hepatocellular Carcinoma.
Wu ZH, Yang DL, Wang L, Liu J.
Front Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fimmu.2021.793343Identification of subgroups along the glycolysis-cholesterol synthesis axis and the development of an associated prognostic risk model.
Zhang E, Chen Y, Bao S, Hou X, Hu J, Mu OYN, Song Y, Shan L.
Hum Genomics · research-article; journal article · DOI 10.1186/s40246-021-00350-3KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.
Zhu L, Xiao F, Yu Y, Wang H, Fang M, Yang Y, Sun H, Wang L, Sheng Y.
Anticancer Drugs · research-article; journal article · DOI 10.1097/cad.0000000000000402KSP inhibitor SB743921 induces death of multiple myeloma cells via inhibition of the NF-κB signaling pathway.
Song IS, Jeong YJ, Nyamaa B, Jeong SH, Kim HK, Kim N, Ko KS, Rhee BD, Han J.
BMB Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.5483/bmbrep.2015.48.10.015The addition of granulocyte-colony stimulating factor shifts the dose limiting toxicity and markedly increases the maximum tolerated dose and activity of the kinesin spindle protein inhibitor SB-743921 in patients with relapsed or refractory lymphoma: results of an international, multicenter phase I/II study.
O'Connor OA, Gerecitano J, Van Deventer H, Hainsworth J, Zullo KM, Saikali K, Seroogy J, Wolff A, Escandón R.
Leuk Lymphoma · clinical trial, phase ii; multicenter study; clinical trial, phase i; journal article · DOI 10.3109/10428194.2015.1004167The novel kinesin spindle protein (KSP) inhibitor SB-743921 exhibits marked activity in in vivo and in vitro models of aggressive large B-cell lymphoma.
Bongero D, Paoluzzi L, Marchi E, Zullo KM, Neisa R, Mao Y, Escandon R, Wood K, O'Connor OA.
Leuk Lymphoma · research support, non-u.s. gov't; journal article · DOI 10.3109/10428194.2015.1020058Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.
Yin Y, Sun H, Xu J, Xiao F, Wang H, Yang Y, Ren H, Wu CT, Gao C, Wang L.
Leuk Lymphoma · research support, non-u.s. gov't; journal article · DOI 10.3109/10428194.2014.956319Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance.
Ma HT, Erdal S, Huang S, Poon RY.
Mol Oncol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.molonc.2014.05.007Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.
Talapatra SK, Anthony NG, Mackay SP, Kozielski F.
J Med Chem · clinical trial, phase ii; clinical trial, phase i; journal article · DOI 10.1021/jm4006274Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm3014597A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose.
Holen KD, Belani CP, Wilding G, Ramalingam S, Volkman JL, Ramanathan RK, Vasist LS, Bowen CJ, Hodge JP, Dar MM, Ho PT.
Cancer Chemother Pharmacol · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article · DOI 10.1007/s00280-010-1346-5