An Efficient and Accessible Hectogram-Scale Synthesis for the Selective O-GlcNAcase Inhibitor Thiamet-G.
Holicek V, Deen M, Bhosale S, Ashmus RA, Vocadlo DJ.
ACS Omega · research-article; journal article · DOI 10.1021/acsomega.4c06141 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
11 träffarRescuable sleep and synaptogenesis phenotypes in a <i>Drosophila</i> model of O-GlcNAc transferase intellectual disability.
Czajewski I, Swain B, Xu J, McDowall L, Ferenbach AT, van Aalten DMF.
Elife · research-article; journal article · DOI 10.7554/elife.90376Local thiamet-G delivery by a thermosensitive hydrogel confers ischemic cardiac repair via myeloid M2-like activation in a STAT6 O-GlcNAcylation-dependent manner.
Zhou W, Tang Q, Wang S, Ding L, Chen M, Liu H, Wu Y, Xiong X, Shen Z, Chen W.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2024.111883Thiamet G as a Potential Treatment for Polycystic Kidney Disease.
Su WC, Hung CF, Wang YC, Peng H, Huang WH, Lo YL, Lo YH, Chen YC, Su HH, Chen YL.
In Vivo · research-article; journal article · DOI 10.21873/invivo.13360O-GlcNAcylation protein disruption by Thiamet G promotes changes on the GBM U87-MG cells secretome molecular signature.
Oliveira-Nunes MC, Julião G, Menezes A, Mariath F, Hanover JA, Evaristo JAM, Nogueira FCS, Dias WB, de Abreu Pereira D, Carneiro K.
Clin Proteomics · research-article; journal article · DOI 10.1186/s12014-021-09317-xO-GlcNAcylation of light chain serine 12 mediates rituximab production doubled by thiamet G.
Kim HY, Park M, Kang C, Heo W, Yoon SM, Lee J, Kim JY.
Bioprocess Biosyst Eng · journal article · DOI 10.1007/s00449-020-02282-zOsteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment.
Takeuchi T, Horimoto Y, Oyama M, Nakatani S, Kobata K, Tamura M, Arata Y, Hatanaka T.
Biol Pharm Bull · journal article · DOI 10.1248/bpb.b20-00221Upregulated protein O-GlcNAcylation promoted functional and structural recovery of the contused spinal cord injury in rats by Thiamet-G treatment.
Liang H, Xu L, Gao A, Shao Y, Yang S, Jiang Z, Ma W, Zhu S, Lin T, Zhang X.
Neurol Res · journal article · DOI 10.1080/01616412.2019.1611202XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
Jiang M, Yu S, Yu Z, Sheng H, Li Y, Liu S, Warner DS, Paschen W, Yang W.
Stroke · research-article; journal article · DOI 10.1161/strokeaha.117.016579Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling.
He Y, Ma X, Li D, Hao J.
J Cereb Blood Flow Metab · research-article; journal article · DOI 10.1177/0271678x16679671Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ.
Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio.797