Stereoselective Pharmacokinetics of Ketamine Administered at a Low Dose in Awake Dogs.
Pargätzi G, Bergadano A, Spadavecchia C, Theurillat R, Thormann W, Levionnois OL.
Animals (Basel) · research-article; journal article · DOI 10.3390/ani14071012 PUBLIKATIONSREGISTRET
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Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Igarashi H, Seiriki K, Nakazawa T, Kasai A, Ago Y, Hashimoto H.
J Pharmacol Sci · journal article · DOI 10.1016/j.jphs.2023.12.005<i>S</i>-Ketamine oral thin film-Part 2: Population pharmacodynamics of <i>S</i>-ketamine, <i>S</i>-norketamine and <i>S</i>-hydroxynorketamine.
Simons P, Olofsen E, van Velzen M, van Lemmen M, van Dasselaar T, Mohr P, Hammes F, van der Schrier R, Niesters M, Dahan A.
Front Pain Res (Lausanne) · research-article; journal article · DOI 10.3389/fpain.2022.946487<i>S</i>-Ketamine Oral Thin Film-Part 1: Population Pharmacokinetics of <i>S</i>-Ketamine, <i>S</i>-Norketamine and <i>S</i>-Hydroxynorketamine.
Simons P, Olofsen E, van Velzen M, van Lemmen M, Mooren R, van Dasselaar T, Mohr P, Hammes F, van der Schrier R, Niesters M, Dahan A.
Front Pain Res (Lausanne) · research-article; journal article · DOI 10.3389/fpain.2022.946486Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression.
Wang Y, Jiang R, Wu Z, Zhou L, Xu J, Huang C, Yang L, Zhu B, Yan E, Liu C, Yang C.
Pharmacol Biochem Behav · research support, non-u.s. gov't; journal article · DOI 10.1016/j.pbb.2021.173226Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers.
Kamp J, van Velzen M, Aarts L, Niesters M, Dahan A, Olofsen E.
Br J Anaesth · research-article; randomized controlled trial; journal article · DOI 10.1016/j.bja.2021.02.034Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.
Otto ME, Bergmann KR, Jacobs G, van Esdonk MJ.
Eur J Clin Pharmacol · research-article; journal article · DOI 10.1007/s00228-021-03104-1(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y.
Pharmacol Biochem Behav · research support, non-u.s. gov't; journal article · DOI 10.1016/j.pbb.2020.172876Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study.
Wang J, Huang J, Yang S, Cui C, Ye L, Wang SY, Yang GP, Pei Q.
Drug Des Devel Ther · comparative study; research-article; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.2147/dddt.s224553Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.
Yang C, Yang J, Luo A, Hashimoto K.
Transl Psychiatry · research support, non-u.s. gov't; research-article; review; journal article · DOI 10.1038/s41398-019-0624-1Is (S)-norketamine an alternative antidepressant for esketamine?
Hashimoto K, Yang C.
Eur Arch Psychiatry Clin Neurosci · letter · DOI 10.1007/s00406-018-0922-2AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.
Yang C, Kobayashi S, Nakao K, Dong C, Han M, Qu Y, Ren Q, Zhang JC, Ma M, Toki H, Yamaguchi JI, Chaki S, Shirayama Y, Nakazawa K, Manabe T, Hashimoto K.
Biol Psychiatry · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.biopsych.2018.05.007Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.
Noppers I, Olofsen E, Niesters M, Aarts L, Mooren R, Dahan A, Kharasch E, Sarton E.
Anesthesiology · comparative study; research support, non-u.s. gov't; research-article; randomized controlled trial; journal article; research support, n.i.h., extramural · DOI 10.1097/aln.0b013e318218a881S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthetized children.
Weber F, Wulf H, Gruber M, Biallas R.
Paediatr Anaesth · comparative study; clinical trial; research support, non-u.s. gov't; journal article · DOI 10.1111/j.1460-9592.2004.01358.x