Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach.
Burrell RC, Turley WA, Bonacorsi SJ.
J Labelled Comp Radiopharm · journal article · DOI 10.1002/jlcr.3312 PUBLIKATIONSREGISTRET
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16 träffarThe microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro.
Brizuela M, Blizzard CA, Chuckowree JA, Dawkins E, Gasperini RJ, Young KM, Dickson TC.
Mol Cell Neurosci · research support, non-u.s. gov't; journal article · DOI 10.1016/j.mcn.2015.02.006Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay.
Yuan L, Fu Y, Zhang D, Xia YQ, Peng Q, Aubry AF, Arnold ME.
J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2014.08.006Neuronal transport defects of the MAP6 KO mouse - a model of schizophrenia - and alleviation by Epothilone D treatment, as observed using MEMRI.
Daoust A, Bohic S, Saoudi Y, Debacker C, Gory-Fauré S, Andrieux A, Barbier EL, Deloulme JC.
Neuroimage · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuroimage.2014.03.071Total synthesis of epothilone D: the nerol/macroaldolization approach.
Wessjohann LA, Scheid GO, Eichelberger U, Umbreen S.
J Org Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jo401355rEpothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities.
Sang F, Feng P, Chen J, Ding Y, Duan X, Zhai J, Ma X, Zhang B, Zhang Q, Lin J, Chen Y.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.08.003Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective.
Cartelli D, Casagrande F, Busceti CL, Bucci D, Molinaro G, Traficante A, Passarella D, Giavini E, Pezzoli G, Battaglia G, Cappelletti G.
Sci Rep · research-article; journal article · DOI 10.1038/srep01837Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice.
Fournet V, de Lavilléon G, Schweitzer A, Giros B, Andrieux A, Martres MP.
J Neurochem · research support, non-u.s. gov't; journal article · DOI 10.1111/jnc.12027The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB, Lee VM, Brunden KR.
J Neurosci · comparative study; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1523/jneurosci.4922-11.2012Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.
Konner J, Grisham RN, Park J, O'Connor OA, Cropp G, Johnson R, Hannah AL, Hensley ML, Sabbatini P, Mironov S, Danishefsky S, Hyman D, Spriggs DR, Dupont J, Aghajanian C.
Invest New Drugs · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article · DOI 10.1007/s10637-011-9765-7A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors.
Monk JP, Villalona-Calero M, Larkin J, Otterson G, Spriggs DS, Hannah AL, Cropp GF, Johnson RG, Hensley ML.
Invest New Drugs · research-article; clinical trial, phase i; journal article · DOI 10.1007/s10637-011-9731-4Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel.
Beer TM, Higano CS, Saleh M, Dreicer R, Hudes G, Picus J, Rarick M, Fehrenbacher L, Hannah AL.
Invest New Drugs · clinical trial, phase ii; journal article · DOI 10.1007/s10637-007-9068-1Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent.
Wang H, Wang Z, Wang S, Li M, Nan L, Rhie JK, Covey JM, Zhang R, Hill DL.
Cancer Chemother Pharmacol · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-004-0965-0Total synthesis of 12,13-desoxyepothilone B (Epothilone D).
Broadrup RL, Sundar HM, Swindell CS.
Bioorg Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bioorg.2004.11.002Epothilone D (Kosan/Roche).
Kolman A.
Curr Opin Investig Drugs · review; journal articleIsolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum.
Julien B, Shah S, Ziermann R, Goldman R, Katz L, Khosla C.
Gene · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0378-1119(00)00149-9