The impact of Thiopeptide antibiotics on inflammatory responses in periodontal tissues through the regulation of the MAPK pathway.
Lyu J, Shen S, Hao Y, Zhou M, Tao J.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2024.112094 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
34 träffarThiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway.
Wang WD, Zeng CY, Shang Y, Ni J, Li GJ, Li LP, Xi SH, Chen SZ.
J Asian Nat Prod Res · journal article · DOI 10.1080/10286020.2024.2343420Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population.
Weinhäuser I, Pereira-Martins DA, Hilberink JR, Brouwers-Vos A, Rego EM, Huls G, Schuringa JJ.
Haematologica · letter; research support, non-u.s. gov't · DOI 10.3324/haematol.2023.283621Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis.
Luo Y, Liu C, Luo Y, Zhang X, Li J, Hu C, Yang S.
Cell Mol Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41423-023-01085-yThiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice.
Esparza K, Oliveira SD, Castellon M, Minshall RD, Onyuksel H.
Mediators Inflamm · research-article; journal article · DOI 10.1155/2023/4035516Thiostrepton, a resurging drug inhibiting the stringent response to counteract antibiotic-resistance and expression of virulence determinants in <i>Neisseria gonorrhoeae</i>.
Talà A, Calcagnile M, Resta SC, Pennetta A, De Benedetto GE, Alifano P.
Front Microbiol · research-article; journal article · DOI 10.3389/fmicb.2023.1104454Thiostrepton confers protection against reactive oxygen species-related apoptosis by restraining FOXM1-triggerred development of gastric cancer.
Liu SX, Zhou Y, Zhao L, Zhou LS, Sun J, Liu GJ, Du YS, Zhou YN.
Free Radic Biol Med · research support, non-u.s. gov't; journal article · DOI 10.1016/j.freeradbiomed.2022.09.018Effects of thiostrepton alone or in combination with selumetinib on triple-negative breast cancer metastasis.
Demirtas Korkmaz F, Dogan Turacli I, Esendagli G, Ekmekci A.
Mol Biol Rep · journal article · DOI 10.1007/s11033-022-07751-0Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling.
Zhang W, Gong M, Zhang W, Mo J, Zhang S, Zhu Z, Wang X, Zhang B, Qian W, Wu Z, Ma Q, Wang Z.
Cell Death Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41419-022-05082-3Structural New Data for Mitochondrial Peroxiredoxin From <i>Trypanosoma cruzi</i> Show High Similarity With Human Peroxiredoxin 3: Repositioning Thiostrepton as Antichagasic Drug.
Rivera-Santiago L, Martínez I, Arroyo-Olarte R, Díaz-Garrido P, Cuevas-Hernandez RI, Espinoza B.
Front Cell Infect Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fcimb.2022.907043The bacterial thiopeptide thiostrepton. An update of its mode of action, pharmacological properties and applications.
Bailly C.
Eur J Pharmacol · review; journal article · DOI 10.1016/j.ejphar.2021.174661Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells.
Kuttikrishnan S, Prabhu KS, Khan AQ, Alali FQ, Ahmad A, Uddin S.
Leuk Lymphoma · research support, non-u.s. gov't; journal article · DOI 10.1080/10428194.2021.1957873Liposomal Thiostrepton Formulation and Its Effect on Breast Cancer Growth Inhibition.
Wongkhieo S, Numdee K, Lam EWF, Choowongkomon K, Kongsema M, Khongkow M.
J Pharm Sci · research support, non-u.s. gov't; journal article · DOI 10.1016/j.xphs.2021.01.018Unique Cellular and Biochemical Features of Human Mitochondrial Peroxiredoxin 3 Establish the Molecular Basis for Its Specific Reaction with Thiostrepton.
Nelson KJ, Messier T, Milczarek S, Saaman A, Beuschel S, Gandhi U, Heintz N, Smalley TL, Lowther WT, Cunniff B.
Antioxidants (Basel) · research-article; journal article · DOI 10.3390/antiox10020150Thiostrepton and miR-216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1.
Cai X, Xiao W, Shen J, Lian H, Lu Y, Liu X, Gu J.
Oncol Lett · research-article; journal article · DOI 10.3892/ol.2020.12254Autophagy induction by thiostrepton for the improvement of anticancer therapy.
Kepp O, Kroemer G.
Autophagy · article-commentary; research support, non-u.s. gov't; journal article · DOI 10.1080/15548627.2020.1758417Thiostrepton: A Novel Therapeutic Drug Candidate for <i>Mycobacterium abscessus</i> Infection.
Kim TH, Hanh BTB, Kim G, Lee DG, Park JW, Lee SE, Kim JS, Kim BS, Ryoo S, Jo EK, Jang J.
Molecules · research-article; journal article · DOI 10.3390/molecules24244511Apicoplast-targeting antibacterials inhibit the growth of Babesia parasites.
Aboulaila M, Munkhjargal T, Sivakumar T, Ueno A, Nakano Y, Yokoyama M, Yoshinari T, Nagano D, Katayama K, El-Bahy N, Yokoyama N, Igarashi I.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.05488-11Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E.
J Biomol Screen · research-article; journal article; research support, n.i.h., extramural · DOI 10.1177/1087057112436557Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.
Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.
Biochem Pharmacol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bcp.2012.01.027Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton.
Wang M, Gartel AL.
Cancer Biol Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.4161/cbt.13.3.18875Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma.
Uddin S, Hussain AR, Ahmed M, Siddiqui K, Al-Dayel F, Bavi P, Al-Kuraya KS.
Haematologica · research-article; journal article · DOI 10.3324/haematol.2011.053421ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro.
Nomura Y, Takabayashi T, Kuroda H, Yukawa Y, Sattasuk K, Akita M, Nozawa A, Tozawa Y.
Plant Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1007/s11103-011-9858-xFoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma.
Ahmed M, Uddin S, Hussain AR, Alyan A, Jehan Z, Al-Dayel F, Al-Nuaim A, Al-Sobhi S, Amin T, Bavi P, Al-Kuraya KS.
J Clin Endocrinol Metab · research support, non-u.s. gov't; journal article · DOI 10.1210/jc.2011-1506Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4.
Walter JD, Hunter M, Cobb M, Traeger G, Spiegel PC.
Nucleic Acids Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/nar/gkr623Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts.
Wang M, Gartel AL.
Mol Cancer Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/1535-7163.mct-11-0536The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
Hegde NS, Sanders DA, Rodriguez R, Balasubramanian S.
Nat Chem · research support, non-u.s. gov't; journal article · DOI 10.1038/nchem.1114Transcript-level responses of Plasmodium falciparum to thiostrepton.
Tarr SJ, Nisbet RE, Howe CJ.
Mol Biochem Parasitol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.molbiopara.2011.05.004Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.
Pandit B, Gartel AL.
PLoS One · research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pone.0017110Thiostrepton maturation involving a deesterification-amidation way to process the C-terminally methylated peptide backbone.
Liao R, Liu W.
J Am Chem Soc · research support, non-u.s. gov't; journal article · DOI 10.1021/ja1111173