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Publikationer i urvalet

18 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2022-04-25

Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates.

Wu H, Li X, He C, Liu Y, Wang C, Yang X, Ma F, Liu J, Xu J.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2022.116776

Bibliografisk träff 2019-11-08

Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug.

Shimizu T, Yamaguchi K, Yamamoto M, Kurioka R, Kino Y, Matsunaga W, Nakao S, Fukuhara H, Tanaka A, Gotoh A, Mabuchi M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.126744

Bibliografisk träff 2019-06-03

Mapping human microbiome drug metabolism by gut bacteria and their genes.

Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL.

Nature · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41586-019-1291-3

Bibliografisk träff 2019-05-24

Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.

O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM, Waddell SJ, Ward SE, Richardson GP, Kros CJ, Derudas M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01325

Bibliografisk träff 2019-05-06

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates.

Xie S, Li X, Yu H, Zhang P, Wang J, Wang C, Xu S, Wu Z, Liu J, Zhu Z, Xu J.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.05.004

Bibliografisk träff 2018-11-22

Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.

Chen H, Yu YZ, Tian XM, Wang CL, Qian YN, Deng ZA, Zhang JX, Lv DJ, Zhang HB, Shen JL, Yuan M, Zhao SC.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.11.029

Bibliografisk träff 2018-03-26

Synthesis, biological evaluation and SAR of naftopidil-based arylpiperazine derivatives.

Chen H, Wang CL, Sun T, Zhou Z, Niu JX, Tian XM, Yuan M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.03.070

Bibliografisk träff 2018-02-01

Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α<sub>1D/1A</sub>-adrenoreceptor subtypes.

Huang JJ, Zhang ZH, He F, Liu XW, Xu XJ, Dai LJ, Liu QM, Yuan M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.01.068

Bibliografisk träff 2015-11-19

Synthesis, structure-activity relationship and biological evaluation of novel arylpiperzines as α1A/1D-AR subselective antagonists for BPH.

Xu F, Chen H, Xu J, Liang X, He X, Shao B, Sun X, Li B, Deng X, Yuan M.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.11.020

Bibliografisk träff 2015-04-07

Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.

Huang J, He F, Huang M, Liu X, Xiong Y, Huang Y, Zhu L, Yang Y, Xu X, Yuan M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.04.005

Bibliografisk träff 2014-11-26

Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines.

Chen H, Xu F, Liang X, Xu BB, Yang ZL, He XL, Huang BY, Yuan M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; evaluation study; journal article · DOI 10.1016/j.bmcl.2014.11.049

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-01-23

Latent hit series hidden in high-throughput screening data.

Varin T, Didiot MC, Parker CN, Schuffenhauer A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm201328e

Bibliografisk träff 2010-06-14

Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.

Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; evaluation study; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01777-09

Bibliografisk träff 2005-02-01

Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.

Li MY, Tsai KC, Xia L.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.11.032

Bibliografisk träff 2000-03-01

(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

Cecchetti V, Schiaffella F, Tabarrini O, Fravolini A.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(00)00016-0