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Publikationer i urvalet

31 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2018-07-31

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.07.068

Bibliografisk träff 2018-02-02

In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.

Gurjar AS, Darekar MN, Yeong KY, Ooi L.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2018.01.029

Bibliografisk träff 2017-12-14

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Roh EJ.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.12.045

Bibliografisk träff 2017-09-22

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Park JE, Elkamhawy A, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.09.043

Bibliografisk träff 2017-02-16

Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents.

Martino MV, Guandalini L, Di Cesare Mannelli L, Menicatti M, Bartolucci G, Dei S, Manetti D, Teodori E, Ghelardini C, Romanelli MN.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2017.02.019

Bibliografisk träff 2016-12-29

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Elkamhawy A, Park JE, Hassan AHE, Ra H, Pae AN, Lee J, Park BG, Moon B, Park HM, Roh EJ.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.12.057

Bibliografisk träff 2016-11-09

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

Kim T, Yang HY, Park BG, Jung SY, Park JH, Park KD, Min SJ, Tae J, Yang H, Cho S, Cho SJ, Song H, Mook-Jung I, Lee J, Pae AN.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.11.017

Bibliografisk träff 2015-03-12

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

Guandalini L, Martino MV, Di Cesare Mannelli L, Bartolucci G, Melani F, Malik R, Dei S, Floriddia E, Manetti D, Orlandi F, Teodori E, Ghelardini C, Romanelli MN.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.03.009

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2013-05-03

Chromatographic separation of piracetam and its metabolite in a mixture of microsomal preparations, followed by an MS/MS analysis.

Sahu K, Siddiqui AA, Shaharyar M, Ahmad N, Anwar M, Ahmad FJ.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.04.053

Bibliografisk träff 2013-04-09

Structure-based identification of OATP1B1/3 inhibitors.

De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.112.084152

Bibliografisk träff 2013-02-26

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor.

Guerrini G, Ciciani G, Costanzo A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Ciattini S.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.02.027

Bibliografisk träff 2012-12-26

Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction.

Kim YS, Jung SH, Park BG, Ko MK, Jang HS, Choi K, Baik JH, Lee J, Lee JK, Pae AN, Cho YS, Min SJ.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2012.12.033

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-01-25

Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.

Guandalini L, Martini E, Di Cesare Mannelli L, Dei S, Manetti D, Scapecchi S, Teodori E, Ghelardini C, Romanelli MN.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.01.045

Bibliografisk träff 2011-03-07

Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.

Martini E, Di Cesare Mannelli L, Bartolucci G, Bertucci C, Dei S, Ghelardini C, Guandalini L, Manetti D, Scapecchi S, Teodori E, Romanelli MN.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm101376k

Bibliografisk träff 2010-03-01

Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.

Ahmed AH, Oswald RE.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm901905j

Bibliografisk träff 2009-09-03

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.

Martini E, Salvicchi A, Ghelardini C, Manetti D, Dei S, Guandalini L, Martelli C, Melchiorre M, Cellai C, Scapecchi S, Teodori E, Romanelli MN.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.08.055

Bibliografisk träff 2008-10-11

Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.

Martini E, Norcini M, Ghelardini C, Manetti D, Dei S, Guandalini L, Melchiorre M, Pagella S, Scapecchi S, Teodori E, Romanelli MN.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.10.017

Bibliografisk träff 2007-06-30

PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.

Marwaha A, Goel RK, Mahajan MP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.06.071

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2004-05-01

Design of new cognition enhancers: from computer prediction to synthesis and biological evaluation.

Geronikaki AA, Dearden JC, Filimonov D, Galaeva I, Garibova TL, Gloriozova T, Krajneva V, Lagunin A, Macaev FZ, Molodavkin G, Poroikov VV, Pogrebnoi SI, Shepeli F, Voronina TA, Tsitlakidou M, Vlad L.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm031086k

Bibliografisk träff 2004-01-01

Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.

Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, Frycia AM, Moureau FG, Klitgaard HV, Gillard MR, Fuks B, Michel P.

J Med Chem · journal article · DOI 10.1021/jm030913e

Bibliografisk träff 2003-07-01

4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.

Manetti D, Martini E, Ghelardini C, Dei S, Galeotti N, Guandalini L, Romanelli MN, Scapecchi S, Teodori E, Bartolini A, Gualtieri F.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00437-2

Bibliografisk träff 2000-05-01

Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.

Manetti D, Ghelardini C, Bartolini A, Bellucci C, Dei S, Galeotti N, Gualtieri F, Romanelli MN, Scapecchi S, Teodori E.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm991170t

Bibliografisk träff 1995-01-01

X-ray crystal structure, partitioning behavior, and molecular modeling study of piracetam-type nootropics: insights into the pharmacophore.

Altomare C, Cellamare S, Carotti A, Casini G, Ferappi M, Gavuzzo E, Mazza F, Carrupt PT, Gaillard P, Testa B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00001a022

Bibliografisk träff 1993-05-01

Synthesis and amnesia-reversal activity of a series of 7- and 5-membered 3-acylamino lactams.

Angelucci L, Calvisi P, Catini R, Cosentino U, Cozzolino R, De Witt P, Ghirardi O, Giannessi F, Giuliani A, Guaraldi D.

J Med Chem · journal article · DOI 10.1021/jm00063a001

Bibliografisk träff 1988-11-01

Synthesis and cognition activating properties of some mono- and bicyclic lactam derivatives.

Altomare C, Carotti A, Casini G, Cellamare S, Ferappi M, Gavuzzo E, Mazza F, Pantaleoni G, Giorgi R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00119a016