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Publikationer i urvalet

13 träffar

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2011-05-05

Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.

Wenlock MC, Barton P, Luker T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.04.133

Bibliografisk träff 2011-02-28

Zwitterionic CRTh2 antagonists.

Luker T, Bonnert R, Paine SW, Schmidt J, Sargent C, Cook AR, Cook A, Gardiner P, Hill S, Weyman-Jones C, Patel A, Thom S, Thorne P.

J Med Chem · journal article · DOI 10.1021/jm1014549

Bibliografisk träff 2010-11-05

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.11.015

Bibliografisk träff 2009-10-23

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.

Weber JE, Oakley AJ, Christ AN, Clark AG, Hayes JD, Hall R, Hume DA, Board PG, Smythe ML, Flanagan JU.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.10.025

Bibliografisk träff 2009-06-25

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.

Stearns BA, Baccei C, Bain G, Broadhead A, Clark RC, Coate H, Evans JF, Fagan P, Hutchinson JH, King C, Lee C, Lorrain DS, Prasit P, Prodanovich P, Santini A, Scott JM, Stock NS, Truong YP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.06.085

Bibliografisk träff 2009-06-14

7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.

Sandham DA, Adcock C, Bala K, Barker L, Brown Z, Dubois G, Budd D, Cox B, Fairhurst RA, Furegati M, Leblanc C, Manini J, Profit R, Reilly J, Stringer R, Schmidt A, Turner KL, Watson SJ, Willis J, Williams G, Wilson C.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.06.042

Bibliografisk träff 2008-03-05

Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Crosignani S, Page P, Missotten M, Colovray V, Cleva C, Arrighi JF, Atherall J, Macritchie J, Martin T, Humbert Y, Gaudet M, Pupowicz D, Maio M, Pittet PA, Golzio L, Giachetti C, Rocha C, Bernardinelli G, Filinchuk Y, Scheer A, Schwarz MK, Chollet A.

J Med Chem · journal article · DOI 10.1021/jm701383e

Bibliografisk träff 2005-03-01

Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists.

Robarge MJ, Bom DC, Tumey LN, Varga N, Gleason E, Silver D, Song J, Murphy SM, Ekema G, Doucette C, Hanniford D, Palmer M, Pawlowski G, Danzig J, Loftus M, Hunady K, Sherf BA, Mays RW, Stricker-Krongrad A, Brunden KR, Harrington JJ, Bennani YL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.12.055

Bibliografisk träff 2005-02-01

Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.

Ulven T, Kostenis E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm049036i

Bibliografisk träff 2002-09-01

Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites.

Hachem A, Roussel P, Ménager E, Grée D, Le Floc'h Y, Grée R, Cerletti C, Rolland Y, Simonet S, Verbeuren T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)00507-3

Bibliografisk träff 1998-06-01

Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.

Cimetière B, Dubuffet T, Muller O, Descombes JJ, Simonet S, Laubie M, Verbeuren TJ, Lavielle G.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00220-0