Ovomemolins: Egg-derived peptides that improved cognitive decline after oral administration in mice.
Nakajima T, Shobako M, Kaneko K, Kurabayashi A, Sato M, Ohinata K.
FASEB Bioadv · research-article; journal article · DOI 10.1096/fba.2023-00149 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
30 träffarSynthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors.
Qasem AMA, Rowan MG, Sanders VR, Millar NS, Blagbrough IS.
ACS Bio Med Chem Au · research-article; journal article · DOI 10.1021/acsbiomedchemau.2c00057Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors.
Gallagher R, Qudah T, Balle T, Chebib M, McLeod MD.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2021.116516Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation.
Mohamed RA, Abdallah DM, El-Brairy AI, Ahmed KA, Ahmed KA, El-Abhar HS.
Molecules · research-article; journal article · DOI 10.3390/molecules26165068Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement.
Palandri J, Smith SL, Heal DJ, Wonnacott S, Bailey CP.
J Psychopharmacol · research-article; journal article · DOI 10.1177/0269881121991570Prefrontal cortex nicotinic receptor inhibition by methyllycaconitine impaired cocaine-associated memory acquisition and retrieval.
Pastor V, Castillo Díaz F, Sanabria VC, Dalto JF, Antonelli MC, Medina JH.
Behav Brain Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbr.2021.113212α7 nAChRs expressed on antigen presenting cells are insensitive to the conventional antagonists α-bungarotoxin and methyllycaconitine.
Mashimo M, Takeshima S, Okuyama H, Matsurida A, Murase M, Ono S, Kawashima K, Fujii T.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2020.106276AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the α4β2 Nicotinic Acetylcholine Receptor.
Qudah T, Quek GX, Indurthi D, Karim N, Halliday JI, Absalom N, McLeod MD, Chebib M.
ACS Chem Neurosci · research support, non-u.s. gov't; journal article · DOI 10.1021/acschemneuro.9b00525Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition.
van Goethem NP, Paes D, Puzzo D, Fedele E, Rebosio C, Gulisano W, Palmeri A, Wennogle LP, Peng Y, Bertrand D, Prickaerts J.
Cell Signal · research support, non-u.s. gov't; journal article · DOI 10.1016/j.cellsig.2019.06.003Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells.
Zheng X, Xie Z, Zhu Z, Liu Z, Wang Y, Wei L, Yang H, Yang H, Liu Y, Bi J.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0111536Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain.
Zouridakis M, Giastas P, Zarkadas E, Chroni-Tzartou D, Bregestovski P, Tzartos SJ.
Nat Struct Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nsmb.2900Methyllycaconitine- and scopolamine-induced cognitive dysfunction: differential reversal effect by cognition-enhancing drugs.
Andriambeloson E, Huyard B, Poiraud E, Wagner S.
Pharmacol Res Perspect · research-article; journal article · DOI 10.1002/prp2.48Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.
Absalom NL, Quek G, Lewis TM, Qudah T, von Arenstorff I, Ambrus JI, Harpsøe K, Karim N, Balle T, McLeod MD, Chebib M.
J Biol Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1074/jbc.m113.475053The role of the α7 subunit of the nicotinic acetylcholine receptor on motor coordination in mice treated with methyllycaconitine and anabasine.
Welch KD, Pfister JA, Gardner DR, Green BT, Panter KE.
J Appl Toxicol · journal article · DOI 10.1002/jat.2894The role of the α7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice.
Welch KD, Green BT, Panter KE, Pfister JA, Gardner DR.
J Appl Toxicol · journal article · DOI 10.1002/jat.2851The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.
Thomsen MS, Mikkelsen JD.
J Neuroimmunol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jneuroim.2012.07.006Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain.
Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Muddana N, Komarneni P.
J Pharmacol Toxicol Methods · journal article · DOI 10.1016/j.vascn.2012.05.003Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses.
Nemecz Á, Taylor P.
J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m111.286583The acute toxicity of the death camas (Zigadenus species) alkaloid zygacine in mice, including the effect of methyllycaconitine coadministration on zygacine toxicity.
Welch KD, Panter KE, Gardner DR, Stegelmeier BL, Green BT, Pfister JA, Cook D.
J Anim Sci · journal article · DOI 10.2527/jas.2010-3444Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors.
Green BT, Welch KD, Cook D, Gardner DR.
Eur J Pharmacol · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.ejphar.2011.04.053Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry--application to neuropharmacokinetics of methyllycaconitine in rats.
Nirogi R, Kandikere V, Komarneni P, Aleti R, Boggavarapu R, Bhyrapuneni G, Muddana N, Mukkanti K.
Biomed Chromatogr · journal article · DOI 10.1002/bmc.1603Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors.
Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M.
ACS Chem Neurosci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/cn100073xDifferent interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor.
Arias HR, Gu RX, Feuerbach D, Wei DQ.
Biochemistry · research support, non-u.s. gov't; journal article · DOI 10.1021/bi901999vSerum elimination profiles of methyllycaconitine and deltaline in cattle following oral administration of larkspur (Delphinium barbeyi).
Green BT, Welch KD, Gardner DR, Stegelmeier BL, Davis TZ, Cook D, Lee ST, Pfister JA, Panter KE.
Am J Vet Res · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.2460/ajvr.70.7.926Investigation of the susceptibility of various strains of mice to methyllycaconitine toxicosis.
Welch KD, Green BT, Panter KE, Gardner DR, Pfister JA, Cook D, Stegelmeier BL.
J Anim Sci · journal article · DOI 10.2527/jas.2008-1577The effect of 7,8-methylenedioxylycoctonine-type diterpenoid alkaloids on the toxicity of methyllycaconitine in mice.
Welch KD, Panter KE, Gardner DR, Green BT, Pfister JA, Cook D, Stegelmeier BL.
J Anim Sci · research support, non-u.s. gov't; journal article · DOI 10.2527/jas.2008-1025Cholinergic modulation of Pavlovian fear conditioning in rats: differential effects of intrahippocampal infusion of mecamylamine and methyllycaconitine.
Vago DR, Kesner RP.
Neurobiol Learn Mem · comparative study; research-article; journal article · DOI 10.1016/j.nlm.2006.11.001Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y.
EMBO J · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/sj.emboj.7600828Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.
Alkondon M, Pereira EF, Wonnacott S, Albuquerque EX.
Mol Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0026-895x(25)09068-6Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems.
Macallan DR, Lunt GG, Wonnacott S, Swanson KL, Rapoport H, Albuquerque EX.
FEBS Lett · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/0014-5793(88)81454-6