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Publikationer i urvalet

13 träffar

Bibliografisk träff 2020-08-31

Inhibition of PI3Kγ by AS605240 plus low-dose tissue plasminogen activator (tPA) combination improves thrombolytic therapy in a rat model of embolic stroke.

Jin R, Zhong W, Liu S, Wang M, Li G.

Neurosci Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.neulet.2020.135339

Bibliografisk träff 2020-01-06

Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer's disease like sporadic dementia in experimental rats.

Alluri R, Ambati SR, Routhu K, Kopalli SR, Koppula S.

EXCLI J · research-article; journal article · DOI 10.17179/excli2019-1997

Bibliografisk träff 2019-06-11

Inhibition of PI3Kγ by AS605240 Protects tMCAO Mice by Attenuating Pro-Inflammatory Signaling and Cytokine Release in Reactive Astrocytes.

Shang S, Liu L, Wu X, Fan F, Hu E, Wang L, Ding Y, Zhang Y, Lu X.

Neuroscience · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuroscience.2019.06.001

Bibliografisk träff 2019-01-01

PI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke.

Jin R, Xiao AY, Li J, Wang M, Li G.

Hypertension · research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/hypertensionaha.118.12001

Bibliografisk träff 2018-05-25

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP.

PLoS One · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pone.0193849

Bibliografisk träff 2012-03-08

The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.

Azzi J, Moore RF, Elyaman W, Mounayar M, El Haddad N, Yang S, Jurewicz M, Takakura A, Petrelli A, Fiorina P, Ruckle T, Abdi R.

Diabetes · research support, non-u.s. gov't; research-article; journal article · DOI 10.2337/db11-0134

Bibliografisk träff 2011-07-01

[The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats].

Song LF, Jiang W, Qing Y, Hu XH, Li Y, Tong QY, Wu XH.

Sichuan Da Xue Xue Bao Yi Xue Ban · research support, non-u.s. gov't; journal article

Bibliografisk träff 2010-12-01

Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.

Seropian IM, Abbate A, Toldo S, Harrington J, Smithson L, Ockaili R, Mezzaroma E, Damilano F, Hirsch E, Van Tassell BW.

J Cardiovasc Pharmacol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1097/fjc.0b013e3181f9a905

Bibliografisk träff 2010-07-01

Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.

Seropian IM, Toldo S, Abbate A, Mezzaroma E, Van Tassell BW.

Circ Res · letter; comment · DOI 10.1161/circresaha.110.224568

Bibliografisk träff 2010-05-26

A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats.

Wei X, Han J, Chen ZZ, Qi BW, Wang GC, Ma YH, Zheng H, Luo YF, Wei YQ, Chen LJ.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2010.05.109

Bibliografisk träff 2010-02-01

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM.

Chem Biol · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.chembiol.2010.01.010

Bibliografisk träff 2009-09-01

[Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice].

Jin K, Song LF, He CM, Wang ZL, Hu XH, Wu XH.

Sichuan Da Xue Xue Bao Yi Xue Ban · research support, non-u.s. gov't; journal article

Bibliografisk träff 2005-08-28

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Camps M, Rückle T, Ji H, Ardissone V, Rintelen F, Shaw J, Ferrandi C, Chabert C, Gillieron C, Françon B, Martin T, Gretener D, Perrin D, Leroy D, Vitte PA, Hirsch E, Wymann MP, Cirillo R, Schwarz MK, Rommel C.

Nat Med · research support, non-u.s. gov't; journal article · DOI 10.1038/nm1284