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Publikationer i urvalet

33 träffar

Bibliografisk träff 2026-08-01

Sparsomycin inhibits translation through a conserved mechanism across all domains of life.

Paranjpe MN, Leroy EC, Syroegin EA, Flemmich L, Thaler J, Gillard M, Bougas A, Kournoutou G, Dinos GP, Renault TT, Micura R, Innis CA, Polikanov YS.

Nucleic Acids Res · research-article; journal article · DOI 10.1093/nar/gkag761

Bibliografisk träff 2023-12-13

Total Syntheses of Sparsomycin and Sparoxomycins A<sub>1</sub> and A<sub>2</sub> via Sulfenate-Anion-Mediated Iterative C-S Bond Formation.

Zhang J, Suzuki K, Ohmori K.

Org Lett · journal article · DOI 10.1021/acs.orglett.3c03791

Bibliografisk träff 2022-02-28

Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo.

Ariefta NR, Pagmadulam B, Nihei CI, Nishikawa Y.

Pharmaceutics · research-article; journal article · DOI 10.3390/pharmaceutics14030544

Bibliografisk träff 2017-10-27

Draft genome sequence of broad-spectrum antibiotic sparsomycin-producing Streptomyces sparsogenes ATCC 25498 from the American Type Culture Collection.

Zhang H, Zhou Q, Lou T, Wang S, Ruan H.

J Glob Antimicrob Resist · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jgar.2017.10.011

Bibliografisk träff 2015-06-09

Sparsomycin Biosynthesis Highlights Unusual Module Architecture and Processing Mechanism in Non-ribosomal Peptide Synthetase.

Rui Z, Huang W, Xu F, Han M, Liu X, Lin S, Zhang W.

ACS Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1021/acschembio.5b00284

Bibliografisk träff 2011-10-28

Sparsomycin-linezolid conjugates can promote ribosomal translocation.

Li S, Cheng X, Zhou Y, Xi Z.

Chembiochem · research support, non-u.s. gov't; journal article · DOI 10.1002/cbic.201100508

Bibliografisk träff 2010-07-01

Absolute binding free energy calculations of sparsomycin analogs to the bacterial ribosome.

Ge X, Roux B.

J Phys Chem B · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jp100579y

Bibliografisk träff 2010-03-01

Calculation of the standard binding free energy of sparsomycin to the ribosomal peptidyl-transferase P-site using molecular dynamics simulations with restraining potentials.

Ge X, Roux B.

J Mol Recognit · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1002/jmr.996

Bibliografisk träff 2006-01-01

Rapid propagation of low-fitness drug-resistant mutants of human immunodeficiency virus type 1 by a streptococcal metabolite sparsomycin.

Miyauchi K, Komano J, Myint L, Futahashi Y, Urano E, Matsuda Z, Chiba T, Miura H, Sugiura W, Yamamoto N.

Antivir Chem Chemother · research support, non-u.s. gov't; journal article · DOI 10.1177/095632020601700401

Bibliografisk träff 2003-12-01

Synthesis and activity of pyrimidinylpropenamide antibiotics: the alkyl analogues of sparsomycin.

Nakajima N, Enomoto T, Watanabe T, Matsuura N, Ubukata M.

Biosci Biotechnol Biochem · research support, non-u.s. gov't; journal article · DOI 10.1271/bbb.67.2556

Bibliografisk träff 2003-08-01

Ribosomal translocation: sparsomycin pushes the button.

Southworth DR, Green R.

Curr Biol · review; journal article · DOI 10.1016/s0960-9822(03)00574-8

Bibliografisk träff 2003-05-01

Catalysis of ribosomal translocation by sparsomycin.

Fredrick K, Noller HF.

Science · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1126/science.1084571

Bibliografisk träff 2002-09-01

Characterization of sparsomycin resistance in Streptomyces sparsogenes.

Lázaro E, Sanz E, Remacha M, Ballesta JP.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.46.9.2914-2919.2002

Bibliografisk träff 1999-08-01

Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.

Porse BT, Kirillov SV, Awayez MJ, Ottenheijm HC, Garrett RA.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.96.16.9003

Bibliografisk träff 1998-12-01

Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues.

Nakajima N, Enomoto T, Matsuura N, Ubukata M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00604-0

Bibliografisk träff 1998-06-01

Kinetics of inhibition of rabbit reticulocyte peptidyltransferase by anisomycin and sparsomycin.

Ioannou M, Coutsogeorgopoulos C, Synetos D.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(24)13281-6

Bibliografisk träff 1997-02-01

Purification and preliminary characterization of (E)-3-(2,4-dioxo-6-methyl-5-pyrimidinyl)acrylic acid synthase, an enzyme involved in biosynthesis of the antitumor agent sparsomycin.

Parry RJ, Hoyt JC.

J Bacteriol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/jb.179.4.1385-1392.1997

Bibliografisk träff 1996-08-01

Mutations in the peptidyl transferase center of 23 S rRNA reveal the site of action of sparsomycin, a universal inhibitor of translation.

Tan GT, DeBlasio A, Mankin AS.

J Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1006/jmbi.1996.0454

Bibliografisk träff 1996-08-01

A sparsomycin-resistant mutant of Halobacterium salinarium lacks a modification at nucleotide U2603 in the peptidyl transferase centre of 23 S rRNA.

Lázaro E, Rodriguez-Fonseca C, Porse B, Ureña D, Garrett RA, Ballesta JP.

J Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1006/jmbi.1996.0455

Bibliografisk träff 1996-06-01

Sparsomycin and its analogues: a new approach for evaluating their potency as inhibitors of peptide bond formation.

Kallia-Raftopoulos S, Synetos D, Ottenheijm HC, van den Broek LA, Coutsogeorgopoulos C.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(25)09000-5

Bibliografisk träff 1991-07-01

Chemical, biochemical and genetic endeavours characterizing the interaction of sparsomycin with the ribosome.

Lazaro E, Van den Broek LA, San Felix A, Ottenheijm HC, Ballesta JP.

Biochimie · research support, non-u.s. gov't; review; journal article · DOI 10.1016/0300-9084(91)90157-v

Bibliografisk träff 1991-01-01

Interaction of the antibiotic sparsomycin with the ribosome.

Lazaro E, San Felix A, van den Broek LA, Ottenheijm HC, Ballesta JP.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.35.1.10

Bibliografisk träff 1989-07-01

Potentiation of cisplatin antitumor activity on L1210 leukemia s.c. by sparsomycin and three of its analogues.

Zylicz Z, Hofs HP, Wagener DJ.

Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/0304-3835(89)90024-4

Bibliografisk träff 1988-12-01

In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models.

Zylicz Z, Wagener DJ, van Rennes H, van der Kleijn E, Lelieveld P, van den Broek LA, Ottenheijm HC.

Invest New Drugs · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1007/bf00173646

Bibliografisk träff 1988-05-01

Direct broth assay for sparsomycin and related nucleoside antitumor antibiotics using reversed-phase high-performance liquid chromatography.

Poehland BL, Chan JA.

J Chromatogr · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0021-9673(01)83861-9

Bibliografisk träff 1988-03-01

The development of sparsomycin as an anti-tumour drug.

Ottenheijm HC, van den Broek LA.

Anticancer Drug Des · journal article

Bibliografisk träff 1987-08-01

Structure-activity relationships of sparsomycin: modification at the hydroxyl group.

Lázaro E, van den Broek LA, Ottenheijm HC, Lelieveld P, Ballesta JP.

Biochimie · research support, non-u.s. gov't; journal article · DOI 10.1016/0300-9084(87)90211-2

Bibliografisk träff 1987-01-01

Pharmacokinetics and toxicology of sparsomycin in beagle dogs.

Zylicz Z, Wagener DJ, Fernandez del Moral P, van Rennes H, Wessels JM, Winograd B, van der Kleijn E, Vree TB, van Haelst U, van den Broek LA.

Cancer Chemother Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1007/bf00253964

Bibliografisk träff 1986-01-01

Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces.

Ottenheijm HC, van den Broek LA, Ballesta JP, Zylicz Z.

Prog Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/s0079-6468(08)70344-8

Bibliografisk träff 1984-12-01

Sulfoxide configuration in sparsomycin determines time-dependent and competitive inhibition of peptidyl transferase.

Ash RJ, Flynn GA, Liskamp RM, Ottenheijm HC.

Biochem Biophys Res Commun · journal article · DOI 10.1016/0006-291x(84)90607-7