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Publikationer i urvalet

17 träffar

Bibliografisk träff 2009-06-01

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.

Chan KK, Wood BM, Fedorov AA, Fedorov EV, Imker HJ, Amyes TL, Richard JP, Almo SC, Gerlt JA.

Biochemistry · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/bi900623r

Bibliografisk träff 2009-03-01

Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.

Bello AM, Konforte D, Poduch E, Furlonger C, Wei L, Liu Y, Lewis M, Pai EF, Paige CJ, Kotra LP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm801224t

Bibliografisk träff 2008-01-12

Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase.

Bello AM, Poduch E, Liu Y, Wei L, Crandall I, Wang X, Dyanand C, Kain KC, Pai EF, Kotra LP.

J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm7010673

Bibliografisk träff 2006-08-01

Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.

Poduch E, Bello AM, Tang S, Fujihashi M, Pai EF, Kotra LP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm060202r

Bibliografisk träff 2002-05-13

Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase.

Wu N, Pai EF.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1074/jbc.m202362200

Bibliografisk träff 2002-03-01

Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography.

Wu N, Gillon W, Pai EF.

Biochemistry · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/bi015758p

Bibliografisk träff 1996-07-01

Antineoplastic activities of 2,3,4-chloro-substituted beta-alkylaminopropiophenone derivatives in CF1 mice and in murine and human tumor cells.

Huang Y, Hall IH.

Anticancer Drugs · comparative study; journal article · DOI 10.1097/00001813-199607000-00018

Bibliografisk träff 1992-12-01

A unique catalytic and inhibitor-binding role for Lys93 of yeast orotidylate decarboxylase.

Smiley JA, Jones ME.

Biochemistry · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/bi00163a027

Bibliografisk träff 1989-09-01

Orotic aciduria fibroblasts express a labile form of UMP synthase.

Perry ME, Jones ME.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0021-9258(19)84861-5

Bibliografisk träff 1983-02-01

Enzymes of de novo pyrimidine biosynthesis in Babesia rodhaini.

Holland JW, Gero AM, O'Sullivan WJ.

J Protozool · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1550-7408.1983.tb01029.x

Bibliografisk träff 1982-11-01

Enhancement of intracellular 5-phosphoribosyl 1-pyrophosphate levels as a major factor in the 6-azauridine-induced stimulation of carbamoyl phosphate synthesis in mouse spleen slices.

Tatibana M, Kita K, Asai T, Ikeda F.

Eur J Biochem · journal article · DOI 10.1111/j.1432-1033.1982.tb07010.x

Bibliografisk träff 1980-12-01

Dependence of the aggregation and conformation states of uridine 5'-phosphate synthase on pyrimidine nucleotides. Evidence for a regulatory site.

Traut TW, Payne RC, Jones ME.

Biochemistry · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/bi00567a018

Bibliografisk träff 1979-12-01

Polymer-linked 6-azauridine 5'-monophosphate, a resin of high bioaffinity to orotidine-5'-phosphate decarboxylase.

Rosemeyer H, Seela F.

J Med Chem · journal article · DOI 10.1021/jm00198a023

Bibliografisk träff 1979-08-01

Theoretical drug design: 6-azauridine-5'-phosphate--its X-ray crystal structure, potential energy maps, and mechanism of inhibition of orotidine-5'-phosphate decarboxylase.

Saenger W, Suck D, Knappenberg M, Dirkx J.

Biopolymers · journal article · DOI 10.1002/bip.1979.360180814

Bibliografisk träff 1978-03-01

Properties of pea seedling uracil phosphoribosyltransferase and its distribution in other plants.

Bressan RA, Murray MG, Gale JM, Ross CW.

Plant Physiol · journal article · DOI 10.1104/pp.61.3.442

Bibliografisk träff 1975-05-01

[Proceedings: Theoretical study on molecular conformation of 6-azauridine-5'-monophosphate].

Knappenberg M, Dirkx J.

Arch Int Physiol Biochim · journal article

Bibliografisk träff 1967-02-01

Orotidine-5'-phosphate decarboxylase and pyrophosphorylase of bean leaves.

Wolcott JH, Ross C.

Plant Physiol · journal article · DOI 10.1104/pp.42.2.275