[Chronic obstructive pulmonary disease : new pharmacotherapeutic options].
Greulich T, Koczulla AR, Vogelmeier C.
Internist (Berl) · journal article; english abstract · DOI 10.1007/s00108-012-3119-1 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
22 träffarLPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing.
Seehase S, Lauenstein HD, Schlumbohm C, Switalla S, Neuhaus V, Förster C, Fieguth HG, Pfennig O, Fuchs E, Kaup FJ, Bleyer M, Hohlfeld JM, Braun A, Sewald K, Knauf S.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0043709Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro.
Milara J, Armengot M, Bañuls P, Tenor H, Beume R, Artigues E, Cortijo J.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1476-5381.2012.01929.xRoflumilast--a phosphodiesterase-4 inhibitor licensed for add-on therapy in severe COPD.
Taegtmeyer AB, Leuppi JD, Kullak-Ublick GA.
Swiss Med Wkly · review; journal article · DOI 10.4414/smw.2012.13628The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice.
Vollert S, Kaessner N, Heuser A, Hanauer G, Dieckmann A, Knaack D, Kley HP, Beume R, Weiss-Haljiti C.
Diabetologia · journal article · DOI 10.1007/s00125-012-2632-zEffect of the phosphodiesterase 4 inhibitor roflumilast on glucose metabolism in patients with treatment-naive, newly diagnosed type 2 diabetes mellitus.
Wouters EF, Bredenbröker D, Teichmann P, Brose M, Rabe KF, Fabbri LM, Göke B.
J Clin Endocrinol Metab · research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1210/jc.2011-2886Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol.
Calverley PM, Martinez FJ, Fabbri LM, Goehring UM, Rabe KF.
Int J Chron Obstruct Pulmon Dis · research support, non-u.s. gov't; research-article; multicenter study; randomized controlled trial; journal article · DOI 10.2147/copd.s31100Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts.
Tannheimer SL, Wright CD, Salmon M.
Respir Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1465-9921-13-28If roflumilast inhibits the innate immunity in the stable patient, what about infection?
Blasco LM.
Clin Respir J · letter · DOI 10.1111/j.1752-699x.2012.00288.xRoflumilast: a novel treatment for chronic obstructive pulmonary disease.
Reid DJ, Pham NT.
Ann Pharmacother · review; journal article · DOI 10.1345/aph.1q646Cost-effectiveness of available treatment options for patients suffering from severe COPD in the UK: a fully incremental analysis.
Hertel N, Kotchie RW, Samyshkin Y, Radford M, Humphreys S, Jameson K.
Int J Chron Obstruct Pulmon Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.2147/copd.s29820Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation.
Knebel NG, Herzog R, Reutter F, Zech K.
J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2012.02.038Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.
Buenestado A, Grassin-Delyle S, Guitard F, Naline E, Faisy C, Israël-Biet D, Sage E, Bellamy JF, Tenor H, Devillier P.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1476-5381.2011.01667.xClinical Considerations for Roflumilast: A New Treatment for COPD.
Kelly Freeman ML.
Consult Pharm · journal article · DOI 10.4140/tcp.n.2012.189Roflumilast (daliresp): a novel phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease.
Baye J.
P T · research-article; journal articleAdditive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells.
Tannheimer SL, Sorensen EA, Haran AC, Mansfield CN, Wright CD, Salmon M.
Pulm Pharmacol Ther · journal article · DOI 10.1016/j.pupt.2012.01.003Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.
Zhong Y, Wu Y, Liu R, Deng Y, Mallipattu SK, Klotman PE, Chuang PY, He JC.
Kidney Int · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1038/ki.2011.467Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease.
Pinner NA, Hamilton LA, Hughes A.
Clin Ther · review; journal article · DOI 10.1016/j.clinthera.2011.12.008[Current anti-inflammatory therapy in patients with chronic obstructive pulmonary disease].
Shmelev EI, Shmeleva NM.
Ter Arkh · lectureAnti-neutrophilic inflammatory activity of ASP3258, a novel phosphodiesterase type 4 inhibitor.
Kubo S, Kobayashi M, Iwata M, Miyata K, Takahashi K, Shimizu Y.
Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2011.10.011Physiological effects of roflumilast at rest and during exercise in COPD.
O'Donnell DE, Bredenbröker D, Brose M, Webb KA.
Eur Respir J · research support, non-u.s. gov't; randomized controlled trial; journal article · DOI 10.1183/09031936.00096511Roflumilast (Daliresp) for COPD.
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Med Lett Drugs Ther · journal article