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Publikationer i urvalet

16 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2013-01-01

MICE models: superior to the HERG model in predicting Torsade de Pointes.

Kramer J, Obejero-Paz CA, Myatt G, Kuryshev YA, Bruening-Wright A, Verducci JS, Brown AM.

Sci Rep · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/srep02100

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-04-07

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.038778

Bibliografisk träff 2010-12-08

Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.

Sinha N, Sen S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2010.11.042

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2008-04-16

Support vector machines classification of hERG liabilities based on atom types.

Jia L, Sun H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.04.028

Bibliografisk träff 2005-06-01

A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.

Tobita M, Nishikawa T, Nagashima R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.03.080

Bibliografisk träff 2004-12-01

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.

Curr Drug Discov Technol · journal article · DOI 10.2174/1570163043334794

Bibliografisk träff 2004-09-01

The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.

Du LP, Tsai KC, Li MY, You QD, Xia L.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.06.070

Bibliografisk träff 2003-08-01

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Keserü GM.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/s0960-894x(03)00492-x

Bibliografisk träff 2001-03-01

Progress toward the development of a safe and effective agent for treating reentrant cardiac arrhythmias: synthesis and evaluation of ibutilide analogues with enhanced metabolic stability and diminished proarrhythmic potential.

Hester JB, Gibson JK, Buchanan LV, Cimini MG, Clark MA, Emmert DE, Glavanovich MA, Imbordino RJ, LeMay RJ, McMillan MW, Perricone SC, Squires DM, Walters RR.

J Med Chem · journal article · DOI 10.1021/jm0004289

Bibliografisk träff 1991-01-01

N-[(omega-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with class III antiarrhythmic activity.

Hester JB, Gibson JK, Cimini MG, Emmert DE, Locker PK, Perricone SC, Skaletzky LL, Sykes JK, West BE.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00105a048