Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs.
Sanford SL, Welfer GA, Freudenthal BD, Opresko PL.
Nat Commun · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41467-020-19115-y PUBLIKATIONSREGISTRET
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Publikationer i urvalet
13 träffarEnzymatic characteristics of Nudix hydrolase 2 (Nud2), an 8-oxo-dGTP hydrolase from Myxococcus xanthus.
Kimura Y, Kajimoto S, Yamamoto Y, Tanaka N.
J Gen Appl Microbiol · journal article · DOI 10.2323/jgam.2019.04.002The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.
Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, Brockmeier U, Metzen E.
BMC Cancer · research-article; journal article · DOI 10.1186/s12885-018-5095-xIdentification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.
Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KYJ.
Chem Biol Drug Des · research support, non-u.s. gov't; journal article · DOI 10.1111/cbdd.12909Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta.
Shimizu M, Gruz P, Kamiya H, Masutani C, Xu Y, Usui Y, Sugiyama H, Harashima H, Hanaoka F, Nohmi T.
Biochemistry · research support, non-u.s. gov't; journal article · DOI 10.1021/bi062238rMTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.
Nakabeppu Y, Kajitani K, Sakamoto K, Yamaguchi H, Tsuchimoto D.
DNA Repair (Amst) · review; journal article · DOI 10.1016/j.dnarep.2006.03.003Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli.
Satou K, Yamada M, Nohmi T, Harashima H, Kamiya H.
Chem Res Toxicol · research support, non-u.s. gov't; journal article · DOI 10.1021/tx050046bInduction of transition and transversion mutations during random mutagenesis PCR by the addition of 2-hydroxy-dATP.
Kamiya H, Ito M, Harashima H.
Biol Pharm Bull · research support, non-u.s. gov't; journal article · DOI 10.1248/bpb.27.621Mutations induced by 2-hydroxy-dATP during in vitro replication with a HeLa extract.
Satou K, Harashima H, Kamiya H.
Nucleic Acids Res Suppl · research support, non-u.s. gov't; journal article · DOI 10.1093/nass/3.1.325A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.
Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.m110566200Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H.
Nucleic Acids Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/nar/29.2.449The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.
Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.274.26.18201Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases.
Lutz MJ, Horlacher J, Benner SA.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00057-2