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Publikationer i urvalet

10 träffar

Bibliografisk träff 2011-09-29

The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier.

Moerman L, Dumolyn C, Boon P, De Vos F.

Nucl Med Biol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.nucmedbio.2011.06.009

Bibliografisk träff 2011-01-24

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET.

Kannan P, Brimacombe KR, Kreisl WC, Liow JS, Zoghbi SS, Telu S, Zhang Y, Pike VW, Halldin C, Gottesman MM, Innis RB, Hall MD.

Proc Natl Acad Sci U S A · research support, n.i.h., intramural; research support, u.s. gov't, p.h.s.; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.1014641108

Bibliografisk träff 2010-04-01

Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.

Seneca N, Zoghbi SS, Shetty HU, Tuan E, Kannan P, Taku A, Innis RB, Pike VW.

Nucl Med Biol · research support, n.i.h., intramural; research-article; journal article · DOI 10.1016/j.nucmedbio.2009.12.010

Bibliografisk träff 2010-03-17

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.

Kreisl WC, Liow JS, Kimura N, Seneca N, Zoghbi SS, Morse CL, Herscovitch P, Pike VW, Innis RB.

J Nucl Med · research support, n.i.h., intramural; clinical trial; research-article; journal article · DOI 10.2967/jnumed.109.070151

Bibliografisk träff 2010-03-08

N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.

Kannan P, Brimacombe KR, Zoghbi SS, Liow JS, Morse C, Taku AK, Pike VW, Halldin C, Innis RB, Gottesman MM, Hall MD.

Drug Metab Dispos · research support, n.i.h., intramural; research-article; journal article · DOI 10.1124/dmd.109.031161

Bibliografisk träff 2010-01-01

Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

Syvänen S, Hammarlund-Udenaes M.

Curr Top Med Chem · review; journal article · DOI 10.2174/156802610792927997

Bibliografisk träff 2009-04-16

Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.

Seneca N, Zoghbi SS, Liow JS, Kreisl W, Herscovitch P, Jenko K, Gladding RL, Taku A, Pike VW, Innis RB.

J Nucl Med · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.2967/jnumed.108.058453

Bibliografisk träff 2008-12-17

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.

Liow JS, Kreisl W, Zoghbi SS, Lazarova N, Seneca N, Gladding RL, Taku A, Herscovitch P, Pike VW, Innis RB.

J Nucl Med · research support, n.i.h., intramural; research-article; journal article · DOI 10.2967/jnumed.108.056226

Bibliografisk träff 2008-09-11

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.

Lazarova N, Zoghbi SS, Hong J, Seneca N, Tuan E, Gladding RL, Liow JS, Taku A, Innis RB, Pike VW.

J Med Chem · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800510m

Bibliografisk träff 1982-06-01

Loperamide in rat intestines: a unique disposition.

Miyazaki H, Nambu K, Hashimoto M.

Life Sci · journal article · DOI 10.1016/0024-3205(82)90294-6