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Publikationer i urvalet

16 träffar

Bibliografisk träff 2021-03-31

Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

Collado-Díaz V, Martinez-Cuesta MÁ, Blanch-Ruiz MA, Sánchez-López A, García-Martínez P, Peris JE, Usach I, Ivorra MD, Lacetera A, Martín-Santamaría S, Esplugues JV, Alvarez A.

Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2021.613449

Bibliografisk träff 2013-05-23

In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients.

Falcinelli E, Francisci D, Belfiori B, Petito E, Guglielmini G, Malincarne L, Mezzasoma A, Sebastiano M, Conti V, Giannini S, Bonora S, Baldelli F, Gresele P.

Thromb Haemost · research support, non-u.s. gov't; journal article · DOI 10.1160/th12-07-0504

Bibliografisk träff 2012-01-01

Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.

Jackson A, Moyle G, Dickinson L, Back D, Khoo S, Taylor J, Gedela K, Abongomera G, Gazzard B, Boffito M.

Antivir Ther · research support, non-u.s. gov't; research-article; randomized controlled trial; journal article · DOI 10.3851/imp1910

Bibliografisk träff 2009-12-01

Interlaboratory measurement differences in intracellular carbovir triphosphate concentrations in HIV-infected patients: sources of variability in processing, shipping, and quantitation.

Goicoechea M, Jain S, Bi L, Sun S, Smith G, Ha B, Richman D, Louie S, Haubrich R, California Collaborative Treatment Group.

J Clin Pharmacol · comparative study; journal article; research support, n.i.h., extramural · DOI 10.1177/0091270009352186

Bibliografisk träff 2009-02-02

Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects.

Moyle G, Boffito M, Fletcher C, Higgs C, Hay PE, Song IH, Lou Y, Yuen GJ, Min SS, Guerini EM.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article · DOI 10.1128/aac.01000-08

Bibliografisk träff 2008-02-01

Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells.

Pruvost A, Théodoro F, Agrofoglio L, Negredo E, Bénech H.

J Mass Spectrom · validation study; journal article · DOI 10.1002/jms.1294

Bibliografisk träff 2005-08-01

Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens.

Hawkins T, Veikley W, St Claire RL, Guyer B, Clark N, Kearney BP.

J Acquir Immune Defic Syndr · journal article · DOI 10.1097/01.qai.0000167155.44980.e8

Bibliografisk träff 2004-08-01

Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels.

Balzarini J, Aquaro S, Hassan-Abdallah A, Daluge SM, Perno CF, McGuigan C.

FEBS Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.febslet.2004.07.049

Bibliografisk träff 2003-09-01

Capillary electrophoresis-ion trap mass spectrometry analysis of Ziagen and its phosphorylated metabolites.

Cai Z, Fung EN, Sinhababu AK.

Electrophoresis · journal article · DOI 10.1002/elps.200305425

Bibliografisk träff 2002-05-01

Intracellular carbovir triphosphate levels in patients taking abacavir once a day.

Harris M, Back D, Kewn S, Jutha S, Marina R, Montaner JS.

AIDS · letter; clinical trial · DOI 10.1097/00002030-200205240-00021

Bibliografisk träff 2002-04-01

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.

Ray AS, Yang Z, Shi J, Hobbs A, Schinazi RF, Chu CK, Anderson KS.

Biochemistry · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/bi0121858

Bibliografisk träff 2002-01-01

Development of enzymatic assays for quantification of intracellular lamivudine and carbovir triphosphate levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients.

Kewn S, Hoggard PG, Sales SD, Jones K, Maher B, Khoo SH, Back DJ.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.46.1.135-143.2002

Bibliografisk träff 2001-04-01

Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate.

Ray AS, Anderson KS.

Nucleosides Nucleotides Nucleic Acids · journal article · DOI 10.1081/ncn-100002528

Bibliografisk träff 1992-10-01

Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity.

Miller WH, Daluge SM, Garvey EP, Hopkins S, Reardon JE, Boyd FL, Miller RL.

J Biol Chem · comparative study; journal article · DOI 10.1016/s0021-9258(19)36820-6

Bibliografisk träff 1991-01-01

Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs.

Parker WB, White EL, Shaddix SC, Ross LJ, Buckheit RW, Germany JM, Secrist JA, Vince R, Shannon WM.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0021-9258(18)52360-7

Bibliografisk träff 1989-06-01

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.

White EL, Parker WB, Macy LJ, Shaddix SC, McCaleb G, Secrist JA, Vince R, Shannon WM.

Biochem Biophys Res Commun · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/0006-291x(89)92611-9