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Publikationer i urvalet

14 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2021-02-11

Furazans in Medicinal Chemistry.

Mancini RS, Barden CJ, Weaver DF, Reed MA.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.0c01901

Bibliografisk träff 2016-07-01

Analogs of the ATP-Sensitive Potassium (KATP) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity.

Roy Chowdhury U, Viker KB, Stoltz KL, Holman BH, Fautsch MP, Dosa PI.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.6b00406

Bibliografisk träff 2013-05-28

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.

Martelli A, Manfroni G, Sabbatini P, Barreca ML, Testai L, Novelli M, Sabatini S, Massari S, Tabarrini O, Masiello P, Calderone V, Cecchetti V.

J Med Chem · journal article · DOI 10.1021/jm400435a

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-05-15

Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

Khelili S, Kihal N, Yekhlef M, de Tullio P, Lebrun P, Pirotte B.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2012.05.011

Bibliografisk träff 2003-08-01

Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.

Cecchetti V, Calderone V, Tabarrini O, Sabatini S, Filipponi E, Testai L, Spogli R, Martinotti E, Fravolini A.

J Med Chem · journal article · DOI 10.1021/jm030791q

Bibliografisk träff 1998-03-01

Synthesis of 2,3,4a,11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carbonitriles as ATP-sensitive potassium channel openers.

Cheng CY, Chiu HI, Chang MJ, Lin YC, Tsai MC, Yu HC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00046-8

Bibliografisk träff 1996-09-01

Synthesis and selective coronary vasodilatory activity of 3,4-dihydro-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol derivatives: novel potassium channel openers.

Cho H, Katoh S, Sayama S, Murakami K, Nakanishi H, Kajimoto Y, Ueno H, Kawasaki H, Aisaka K, Uchida I.

J Med Chem · journal article · DOI 10.1021/jm960270l

Bibliografisk träff 1993-07-01

Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.

Manley PW, Quast U, Andres H, Bray K.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00066a009

Bibliografisk träff 1993-07-01

2,2-Dialkylnaphthalen-1-ones as new potassium channel activators.

Almansa C, Gómez LA, Cavalcanti FL, Rodríguez R, Carceller E, Bartrolí J, García-Rafanell J, Forn J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00067a011

Bibliografisk träff 1992-11-01

Thiophene systems. 14. Synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxythieno[3,2-b]pyrans and related compounds as new potassium channel activators.

Sanfilippo PJ, McNally JJ, Press JB, Fitzpatrick LJ, Urbanski MJ, Katz LB, Giardino E, Falotico R, Salata J, Moore JB.

J Med Chem · journal article · DOI 10.1021/jm00101a020

Bibliografisk träff 1991-03-01

Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.

Buckle DR, Arch JR, Edge C, Foster KA, Houge-Frydrych CS, Pinto IL, Smith DG, Taylor JF, Taylor SG, Tedder JM.

J Med Chem · journal article · DOI 10.1021/jm00107a008

Bibliografisk träff 1986-11-01

Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans.

Ashwood VA, Buckingham RE, Cassidy F, Evans JM, Faruk EA, Hamilton TC, Nash DJ, Stemp G, Willcocks K.

J Med Chem · journal article · DOI 10.1021/jm00161a011