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Publikationer i urvalet

26 träffar

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2019-06-24

Sleep modulating agents.

Choi Y, Raymer BK.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2019.06.043

Bibliografisk träff 2017-03-20

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.

Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA.

J Med Chem · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b00141

Bibliografisk träff 2011-09-14

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).

O'Neill DJ, Adedoyin A, Bray JA, Deecher DC, Fensome A, Goldberg JA, Harrison J, Leventhal L, Mann C, Mark L, Nogle L, Sullivan NR, Spangler TB, Terefenko EA, Trybulski EJ, Uveges AJ, Vu A, Whiteside GT, Zhang P.

J Med Chem · journal article · DOI 10.1021/jm200733r

Bibliografisk träff 2010-06-01

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P.

J Med Chem · journal article · DOI 10.1021/jm100053t

Bibliografisk träff 2010-03-15

Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.

Sabatucci JP, Mahaney PE, Leiter J, Johnston G, Burroughs K, Cosmi S, Zhang Y, Ho D, Deecher DC, Trybulski E.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.03.059

Bibliografisk träff 2010-02-06

Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.

Prado-Prado FJ, García-Mera X, González-Díaz H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.01.068

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2009-09-01

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

Zhang P, Terefenko EA, Bray J, Deecher D, Fensome A, Harrison J, Kim C, Koury E, Mark L, McComas CC, Mugford CA, Trybulski EJ, Vu AT, Whiteside GT, Mahaney PE.

J Med Chem · journal article · DOI 10.1021/jm900888c

Bibliografisk träff 2009-07-23

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

Kim CY, Mahaney PE, McConnell O, Zhang Y, Manas E, Ho DM, Deecher DC, Trybulski EJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.07.053

Bibliografisk träff 2009-05-03

A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.

Lapinsky DJ, Aggarwal S, Huang Y, Surratt CK, Lever JR, Foster JD, Vaughan RA.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2009.04.057

Bibliografisk träff 2009-03-18

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.

Vu AT, Cohn ST, Terefenko EA, Moore WJ, Zhang P, Mahaney PE, Trybulski EJ, Goljer I, Dooley R, Bray JA, Johnston GH, Leiter J, Deecher DC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2009.03.054

Bibliografisk träff 2008-10-11

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

Zhang P, Terefenko EA, McComas CC, Mahaney PE, Vu A, Trybulski E, Koury E, Johnston G, Bray J, Deecher D.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.10.026

Bibliografisk träff 2008-06-17

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC.

J Med Chem · journal article · DOI 10.1021/jm8002262

Bibliografisk träff 2007-01-25

Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.

Vaughan RA, Sakrikar DS, Parnas ML, Adkins S, Foster JD, Duval RA, Lever JR, Kulkarni SS, Hauck-Newman A.

J Biol Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m610633200

Bibliografisk träff 2003-12-01

Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.

Orjales A, Mosquera R, Toledo A, Pumar MC, García N, Cortizo L, Labeaga L, Innerárity A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0309349

Bibliografisk träff 2002-09-01

Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.

Houlihan WJ, Kelly L, Pankuch J, Koletar J, Brand L, Janowsky A, Kopajtic TA.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010302r

Bibliografisk träff 2002-09-01

Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.

Houlihan WJ, Ahmad UF, Koletar J, Kelly L, Brand L, Kopajtic TA.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010301z

Bibliografisk träff 2002-09-01

Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter.

Kulkarni SS, Newman AH, Houlihan WJ.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0102093

Bibliografisk träff 2000-07-01

An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes.

Prakash KR, Trzcinska M, Johnson KM, Kozikowski AP.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0960-894x(00)00269-9

Bibliografisk träff 1999-08-01

Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.

Bucholtz EC, Brown RL, Tropsha A, Booth RG, Wyrick SD.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm980428x

Bibliografisk träff 1996-12-01

Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.

Houlihan WJ, Boja JW, Parrino VA, Kopajtic TA, Kuhar MJ.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960288w

Bibliografisk träff 1994-11-01

Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.

Myers AM, Charifson PS, Owens CE, Kula NS, McPhail AT, Baldessarini RJ, Booth RG, Wyrick SD.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00050a008

Bibliografisk träff 1994-05-01

Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.

Goodman MM, Kung MP, Kabalka GW, Kung HF, Switzer R.

J Med Chem · journal article · DOI 10.1021/jm00036a020

Bibliografisk träff 1992-03-01

Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.

Carroll FI, Lewin AH, Boja JW, Kuhar MJ.

J Med Chem · review; journal article · DOI 10.1021/jm00084a001

Bibliografisk träff 1983-05-01

Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols.

Houlihan WJ, Gogerty JH, Parrino VA, Ryan E.

J Med Chem · journal article · DOI 10.1021/jm00359a025