Antineoplastic Agents. 607. Emetine Auristatins.
Pettit GR, Melody N, Chapuis JC.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.0c00031 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
13 träffarMetabolomic tools used in marine natural product drug discovery.
Stuart KA, Welsh K, Walker MC, Edrada-Ebel R.
Expert Opin Drug Discov · review; journal article · DOI 10.1080/17460441.2020.1722636Interaction of diazonamide A with tubulin.
Bai R, Cruz-Monserrate Z, Fenical W, Pettit GR, Hamel E.
Arch Biochem Biophys · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.abb.2019.108217Convergent synthesis of hydrophilic monomethyl dolastatin 10 based drug linkers for antibody-drug conjugation.
Yang K, Chen B, Gianolio DA, Stefano JE, Busch M, Manning C, Alving K, Gregory RC, Brondyk WH, Miller RJ, Dhal PK.
Org Biomol Chem · journal article · DOI 10.1039/c9ob01639bSynthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications.
Akaiwa M, Martin T, Mendelsohn BA.
ACS Omega · research-article; journal article · DOI 10.1021/acsomega.8b00093Synthesis and evaluation of novel dolastatin 10 derivatives for versatile conjugations.
Yokosaka S, Izawa A, Sakai C, Sakurada E, Morita Y, Nishio Y.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2018.02.011Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains.
Dugal-Tessier J, Barnscher SD, Kanai A, Mendelsohn BA.
J Nat Prod · journal article · DOI 10.1021/acs.jnatprod.7b00359A practical approach to asymmetric synthesis of dolastatin 10.
Zhou W, Nie XD, Zhang Y, Si CM, Zhou Z, Sun X, Wei BG.
Org Biomol Chem · journal article · DOI 10.1039/c7ob01395gDiscovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ.
J Med Chem · journal article · DOI 10.1021/jm501649kAntineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10.
Pettit GR, Hogan F, Toms S.
J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np1007334Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10.
Prokopiou EM, Cooper PA, Pettit GR, Bibby MC, Shnyder SD.
Mol Med Rep · journal article · DOI 10.3892/mmr_00000256Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E.
Biochem Pharmacol · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/0006-2952(93)90051-wDolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Bai R, Pettit GR, Hamel E.
Biochem Pharmacol · comparative study; journal article · DOI 10.1016/0006-2952(90)90613-p