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Publikationer i urvalet

19 träffar

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2014-08-06

Rational use of plasma protein and tissue binding data in drug design.

Liu X, Wright M, Hop CE.

J Med Chem · review; journal article · DOI 10.1021/jm5007935

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2010-09-15

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Ekins S, Williams AJ, Xu JJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.035113

Bibliografisk träff 2010-07-01

Developing structure-activity relationships for the prediction of hepatotoxicity.

Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ.

Chem Res Toxicol · journal article · DOI 10.1021/tx1000865

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2009-09-30

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Vincent F, Nguyen MT, Emerling DE, Kelly MG, Duncton MA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.09.086

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2002-12-01

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW.

J Pharmacol Exp Ther · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1124/jpet.102.039255

Bibliografisk träff 1984-02-01

Synthesis and anticonvulsant activity of some substituted lactams and amides.

Brouillette WJ, Grunewald GL.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00368a017

Bibliografisk träff 1981-05-01

Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines.

Albright JD, Moran DB, Wright WB, Collins JB, Beer B, Lippa AS, Greenblatt EN.

J Med Chem · journal article · DOI 10.1021/jm00137a020

Bibliografisk träff 1979-02-01

Bicyclic pyrazolines, potential central nervous system depressants and antiinflammatory agents.

Krapcho J, Turk CF.

J Med Chem · journal article · DOI 10.1021/jm00188a018

Bibliografisk träff 1979-01-01

The benzodiazepine story.

Sternbach LH.

J Med Chem · historical article; journal article · DOI 10.1021/jm00187a001

Bibliografisk träff 1978-10-01

Derivatives of 1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione as anxiolytic agents.

Wright WB, Brabander HJ, Greenblatt EN, Day IP, Hardy RA.

J Med Chem · journal article · DOI 10.1021/jm00208a017

Bibliografisk träff 1978-08-01

A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics.

Clarke FH, Hill RT, Koo J, Lopano RM, Maseda MA, Smith M, Soled S, VonVeh G, Vlattas I.

J Med Chem · journal article · DOI 10.1021/jm00206a013

Bibliografisk träff 1977-05-01

Synthesis and central nervous system activity of 2-arylidene-4-aminoalkyl-2H-1,4-benzoxazin-3(4H)-ones and related compounds.

Turk CF, Krapcho J, Michel IM, Weinryb I.

J Med Chem · journal article · DOI 10.1021/jm00215a024