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Publikationer i urvalet

41 träffar

Bibliografisk träff 2024-08-01

Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening.

Puls K, Olivé-Marti AL, Hongnak S, Lamp D, Spetea M, Wolber G.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.4c00590

Bibliografisk träff 2022-09-22

A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.

Khan MIH, Sawyer BJ, Akins NS, Le HV.

Eur J Med Chem · systematic review; journal article · DOI 10.1016/j.ejmech.2022.114785

Bibliografisk träff 2022-01-07

Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.

Smith MT, Kong D, Kuo A, Imam MZ, Williams CM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01915

Bibliografisk träff 2020-06-12

G-Protein biased opioid agonists: 3-hydroxy-<i>N</i>-phenethyl-5-phenylmorphans with three-carbon chain substituents at C9.

Gutman ES, Bow E, Li F, Sulima A, Kaska S, Crowley R, Prisinzano TE, Lee YS, Hassan SA, Imler GH, Deschamps JR, Jacobson AE, Rice KC.

RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00104j

Bibliografisk träff 2019-01-09

Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Ständer S, Loser K, Wünsch B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01609

Bibliografisk träff 2018-07-10

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Tan L, Yan W, McCorvy JD, Cheng J.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.8b00435

Bibliografisk träff 2017-07-18

Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene.

Yilmaz A, Crowley RS, Sherwood AM, Prisinzano TE.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.7b00327

Bibliografisk träff 2017-04-19

Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

Sherwood AM, Crowley RS, Paton KF, Biggerstaff A, Neuenswander B, Day VW, Kivell BM, Prisinzano TE.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b00148

Bibliografisk träff 2017-04-03

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor.

Zheng Z, Huang XP, Mangano TJ, Zou R, Chen X, Zaidi SA, Roth BL, Stevens RC, Katritch V.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b00109

Bibliografisk träff 2017-03-13

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL.

Nat Chem Biol · research-article; journal article · DOI 10.1038/nchembio.2334

Bibliografisk träff 2016-12-13

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability.

Crowley RS, Riley AP, Sherwood AM, Groer CE, Shivaperumal N, Biscaia M, Paton K, Schneider S, Provasi D, Kivell BM, Filizola M, Prisinzano TE.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.6b01235

Bibliografisk träff 2015-07-03

Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists.

Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2015.06.092

Bibliografisk träff 2014-12-09

Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues.

Riley AP, Groer CE, Young D, Ewald AW, Kivell BM, Prisinzano TE.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm501521d

Bibliografisk träff 2014-08-23

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK.

Eur J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2014.07.077

Bibliografisk träff 2014-08-12

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2014.08.012

Bibliografisk träff 2014-07-30

Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.

Vasiljevik T, Groer CE, Lehner K, Navarro H, Prisinzano TE.

J Nat Prod · review-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np5002048

Bibliografisk träff 2014-07-18

Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.

Le Naour M, Lunzer MM, Powers MD, Kalyuzhny AE, Benneyworth MA, Thomas MJ, Portoghese PS.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm500159d

Bibliografisk träff 2014-02-21

A perspective on natural products research and ethnopharmacology in Mexico: the eagle and the serpent on the prickly pear cactus.

Heinrich M, Frei Haller B, Leonti M.

J Nat Prod · review; journal article · DOI 10.1021/np4009927

Bibliografisk träff 2013-12-11

The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.

Rajagopalan R, Bandyopadhyaya A, Rajagopalan DR, Rajagopalan P.

Bioorg Med Chem Lett · comparative study; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2013.12.024

Bibliografisk träff 2013-04-04

Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.

Polepally PR, White K, Vardy E, Roth BL, Ferreira D, Zjawiony JK.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2013.03.111

Bibliografisk träff 2012-03-01

Semisynthetic neoclerodanes as kappa opioid receptor probes.

Lovell KM, Vasiljevik T, Araya JJ, Lozama A, Prevatt-Smith KM, Day VW, Dersch CM, Rothman RB, Butelman ER, Kreek MJ, Prisinzano TE.

Bioorg Med Chem · research support, n.i.h., intramural; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2012.02.040

Bibliografisk träff 2011-12-07

Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2011.11.128

Bibliografisk träff 2011-02-21

Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A.

Lozama A, Cunningham CW, Caspers MJ, Douglas JT, Dersch CM, Rothman RB, Prisinzano TE.

J Nat Prod · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np1007872

Bibliografisk träff 2010-11-11

Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids.

Fichna J, Lewellyn K, Yan F, Roth BL, Zjawiony JK.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2010.11.046

Bibliografisk träff 2010-08-05

Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A.

Lee DY, Yang L, Xu W, Deng G, Guo L, Liu-Chen LY.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2010.08.001

Bibliografisk träff 2010-04-28

Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.

Yamaotsu N, Fujii H, Nagase H, Hirono S.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2010.04.069

Bibliografisk träff 2009-08-06

Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.

Ghirmai S, Azar MR, Cashman JR.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2009.07.069

Bibliografisk träff 2008-12-14

Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.

Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2008.12.012

Bibliografisk träff 2008-04-02

Herkinorin analogues with differential beta-arrestin-2 interactions.

Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm701162g

Bibliografisk träff 2008-02-23

Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.

Kane BE, McCurdy CR, Ferguson DM.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm701040v