Further Insight into the Interactions of the Cytotoxic Macrolides Laulimalide and Peloruside A with Their Common Binding Site.
Castro-Alvarez A, Pineda O, Vilarrasa J.
ACS Omega · research-article; journal article · DOI 10.1021/acsomega.7b01723 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
22 träffarModulation of lateral and longitudinal interdimeric interactions in microtubule models by Laulimalide and Peloruside A association: A molecular modeling approach on the mechanism of microtubule stabilizing agents.
Zúñiga MA, Alderete JB, Jaña GA, Fernandez PA, Ramos MJ, Jiménez VA.
Chem Biol Drug Des · research support, non-u.s. gov't; journal article · DOI 10.1111/cbdd.13168Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
Zúñiga MA, Alderete JB, Jaña GA, Jiménez VA.
J Comput Aided Mol Des · journal article · DOI 10.1007/s10822-017-0029-2Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide-tubulin pharmacophore.
Churchill CD, Klobukowski M, Tuszynski JA.
J Biomol Struct Dyn · journal article · DOI 10.1080/07391102.2015.1078115βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.
Kanakkanthara A, Rowe MR, Field JJ, Northcote PT, Teesdale-Spittle PH, Miller JH.
Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2015.06.001The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.
Churchill CD, Klobukowski M, Tuszynski JA.
Chem Biol Drug Des · research support, non-u.s. gov't; journal article · DOI 10.1111/cbdd.12475Structural basis of microtubule stabilization by laulimalide and peloruside A.
Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO.
Angew Chem Int Ed Engl · research support, non-u.s. gov't; journal article · DOI 10.1002/anie.201307749Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.
Hanna R, Maass DR, Atkinson PH, Northcote PT, Teesdale-Spittle PH, Bellows DS, Miller JH.
Mol Biosyst · research support, non-u.s. gov't; journal article · DOI 10.1039/c3mb70380kResistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding.
Kanakkanthara A, Eras J, Northcote PT, Cabral F, Miller JH.
Curr Cancer Drug Targets · research support, non-u.s. gov't; journal article · DOI 10.2174/1568009613666131113101151Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.
Best HA, Matthews JH, Heathcott RW, Hanna R, Leahy DC, Coorey NV, Bellows DS, Atkinson PH, Miller JH.
Mol Biosyst · research support, non-u.s. gov't; journal article · DOI 10.1039/c3mb70211aLaulimalide induces dose-dependent modulation of microtubule behaviour in the C. elegans embryo.
Bajaj M, Srayko M.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0071889Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases.
Rohena CC, Peng J, Johnson TA, Crews P, Mooberry SL.
Biochem Pharmacol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bcp.2013.01.030Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization.
Bennett MJ, Chan GK, Rattner JB, Schriemer DC.
Cell Cycle · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.4161/cc.21411Peloruside, laulimalide, and noscapine interactions with beta-tubulin.
Gajewski MM, Alisaraie L, Tuszynski JA.
Pharm Res · research support, non-u.s. gov't; review; journal article · DOI 10.1007/s11095-012-0809-2Total synthesis of laulimalide: synthesis of the northern and southern fragments.
Trost BM, Seganish WM, Chung CK, Amans D.
Chemistry · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/chem.201102898Total synthesis of laulimalide: assembly of the fragments and completion of the synthesis of the natural product and a potent analogue.
Trost BM, Amans D, Seganish WM, Chung CK.
Chemistry · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/chem.201102899Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
Khrapunovich-Baine M, Menon V, Yang CP, Northcote PT, Miller JH, Angeletti RH, Fiser A, Horwitz SB, Xiao H.
J Biol Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m110.162214Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
Bennett MJ, Barakat K, Huzil JT, Tuszynski J, Schriemer DC.
Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.chembiol.2010.05.019Evaluating transition-metal-catalyzed transformations for the synthesis of laulimalide.
Trost BM, Amans D, Seganish WM, Chung CK.
J Am Chem Soc · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ja907924jThe laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue.
Gollner A, Altmann KH, Gertsch J, Mulzer J.
Chemistry · research support, non-u.s. gov't; journal article · DOI 10.1002/chem.200802605Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.
Clark EA, Hills PM, Davidson BS, Wender PA, Mooberry SL.
Mol Pharm · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/mp060016hLaulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.
Mooberry SL, Tien G, Hernandez AH, Plubrukarn A, Davidson BS.
Cancer Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article