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Publikationer i urvalet

36 träffar

Bibliografisk träff 2024-08-05

Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment.

Citarella A, Cavinato M, Rosini E, Shehi H, Ballabio F, Camilloni C, Fasano V, Silvani A, Passarella D, Pollegioni L, Nardini M.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.4c00190

Bibliografisk träff 2024-03-19

Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and Fluorescence Imaging.

Wang GY, Yan DX, Rong RX, Shi BY, Lin GJ, Yin F, Wei WT, Li XL, Wang KR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.4c00304

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2023-01-17

Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges.

Mushtaq A, Azam U, Mehreen S, Naseer MM.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115119

Bibliografisk träff 2022-11-15

New cycloalkyl[b]thiophenylnicotinamide-based α-glucosidase inhibitors as promising anti-diabetic agents: Synthesis, in silico study, in vitro and in vivo evaluations.

Wang KM, Ge YX, Zhang J, Chen YT, Zhang NY, Gu JS, Fang L, Zhang XL, Zhang J, Jiang CS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.129069

Bibliografisk träff 2022-07-22

Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates.

Yang JX, Li JJ, Yin FQ, Wang GY, Wei WT, Li XL, Wang KR.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114621

Bibliografisk träff 2021-04-22

Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.

Li RF, Yang JX, Liu J, Ai GM, Zhang HY, Xu LY, Chen SB, Zhang HX, Li XL, Cao ZR, Wang KR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00036

Bibliografisk träff 2020-12-19

Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.

Takashima K, Sakano M, Kinouchi E, Nakamura S, Marumoto S, Ishikawa F, Ninomiya K, Nakanishi I, Morikawa T, Tanabe G.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127751

Bibliografisk träff 2019-10-15

Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent α-glucosidase inhibitors.

Saeedi M, Mohammadi-Khanaposhtani M, Asgari MS, Asgari MS, Eghbalnejad N, Imanparast S, Faramarzi MA, Larijani B, Mahdavi M, Akbarzadeh T.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.115148

Bibliografisk träff 2018-02-26

Synthesis, molecular modeling and evaluation of α-glucosidase inhibition activity of 3,4-dihydroxy piperidines.

Kasturi SP, Surarapu S, Uppalanchi S, Dwivedi S, Yogeeswari P, Sigalapalli DK, Bathini NB, Ethiraj KS, Anireddy JS.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.02.072

Bibliografisk träff 2017-10-14

Polyhydroxylated azetidine iminosugars: Synthesis, glycosidase inhibitory activity and molecular docking studies.

Lawande PP, Sontakke VA, Kumbhar NM, Bhagwat TR, Ghosh S, Shinde VS.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.10.025

Bibliografisk träff 2017-08-18

Quinazoline-1-deoxynojirimycin hybrids as high active dual inhibitors of EGFR and α-glucosidase.

Zhang Y, Gao H, Liu R, Liu J, Chen L, Li X, Zhao L, Wang W, Li B.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.08.035

Bibliografisk träff 2017-07-14

α-Geminal disubstituted pyrrolidine iminosugars and their C-4-fluoro analogues: Synthesis, glycosidase inhibition and molecular docking studies.

Gavale KS, Chavan SR, Kumbhar N, Kawade S, Doshi P, Khan A, Dhavale DD.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2017.07.026

Bibliografisk träff 2017-06-14

Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors.

Kasturi S, Surarapu S, Bathoju CC, Uppalanchi S, Dwivedi S, Perumal Y, Sigalapalli DK, Babu BN, Ethiraj KS, Anireddy JS.

Medchemcomm · research-article; journal article · DOI 10.1039/c7md00162b

Bibliografisk träff 2017-05-02

Synthesis and α-glucosidase inhibition activity of dihydroxy pyrrolidines.

Kasturi S, Surarapu S, Uppalanchi S, Anireddy JS, Dwivedi S, Anantaraju HS, Perumal Y, Sigalapalli DK, Babu BN, Ethiraj KS.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.04.078

Bibliografisk träff 2016-11-30

Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition.

Hatano A, Kanno Y, Kondo Y, Sunaga Y, Umezawa H, Okada M, Yamada H, Iwaki R, Kato A, Fukui K.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2016.11.053

Bibliografisk träff 2016-06-07

Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.

Tanabe G, Xie W, Balakishan G, Amer MF, Tsutsui N, Takemura H, Nakamura S, Akaki J, Ninomiya K, Morikawa T, Nakanishi I, Muraoka O.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.06.013

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2015-09-25

Quaternary Indolizidine and Indolizidone Iminosugars as Potential Immunostimulating and Glycosidase Inhibitory Agents: Synthesis, Conformational Analysis, Biological Activity, and Molecular Docking Study.

Pawar NJ, Parihar VS, Khan A, Joshi R, Dhavale DD.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b00951

Bibliografisk träff 2014-10-07

γ-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents.

Markad PR, Sonawane DP, Ghosh S, Chopade BA, Kumbhar N, Louat T, Herman J, Waer M, Herdewijn P, Dhavale DD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.09.034

Bibliografisk träff 2014-06-11

Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.

Natori Y, Sakuma T, Yoshimura Y, Kinami K, Hirokami Y, Sato K, Adachi I, Kato A, Takahata H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.06.001

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2013-04-09

Structure-based identification of OATP1B1/3 inhibitors.

De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.112.084152

Bibliografisk träff 2012-11-19

α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.

Kato A, Hayashi E, Miyauchi S, Adachi I, Imahori T, Natori Y, Yoshimura Y, Nash RJ, Shimaoka H, Nakagome I, Koseki J, Hirono S, Takahata H.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm301304e

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-05-24

Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.

Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM, Rose DR.

Bioorg Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2011.05.033

Bibliografisk träff 2010-11-30

The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.

Natori Y, Imahori T, Murakami K, Yoshimura Y, Nakagawa S, Kato A, Adachi I, Takahata H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.11.112

Bibliografisk träff 2010-09-29

Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.

Mohan S, Sim L, Rose DR, Pinto BM.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.09.059

Bibliografisk träff 2010-02-01

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.

J Med Chem · journal article · DOI 10.1021/jm901371v