Drug development and potential targets for Cushing's syndrome.
Wei W, Xu Q, Wu L, Gong G, Tian Y, Huang H, Li Z.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116333 PUBLIKATIONSREGISTRET
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13 träffarIdentification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.
iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.
Sutherland JJ, Yonchev D, Fekete A, Urban L.
Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.
Hall A, Chanteux H, Ménochet K, Ledecq M, Schulze MED.
J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.0c02245DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.
Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015Structure-based identification of OATP1B1/3 inhibitors.
De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.
Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.112.084152Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.
PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Toropov AA, Toropova AP, Raska I, Benfenati E.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.12.043Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.
Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326kChemical genetics reveals a complex functional ground state of neural stem cells.
Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.
Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2Cell-based screen for identification of inhibitors of tubulin polymerization.
Kokoshka JM, Ireland CM, Barrows LR.
J Nat Prod · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/np960144k