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Publikationer i urvalet

23 träffar

Bibliografisk träff 2005-03-21

2-Haloacrylate reductase, a novel enzyme of the medium chain dehydrogenase/reductase superfamily that catalyzes the reduction of a carbon-carbon double bond of unsaturated organohalogen compounds.

Kurata A, Kurihara T, Kamachi H, Esaki N.

J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.m414605200

Bibliografisk träff 2004-12-01

Re-evaluation of archival material for neuronal cell injury produced by L-2-chloropropionic acid in the rat brain.

Duffell S, Lock EA.

Neurotoxicology · comparative study; evaluation study; journal article · DOI 10.1016/j.neuro.2004.01.009

Bibliografisk träff 2001-06-01

2-Halopropionic acid-induced cerebellar granule cell necrosis in the rat: in vivo and in vitro studies.

Lock EA, Gyte A, Sturgess NC, Duffell S, Wyatt I.

Neurotoxicology · journal article · DOI 10.1016/s0161-813x(01)00027-4

Bibliografisk träff 2001-02-01

Neuroprotective effects of MK-801 on L-2-chloropropionic acid-induced neurotoxicity.

Williams RE, Lock EA, Bachelard HS.

J Neurochem · research support, non-u.s. gov't; journal article · DOI 10.1046/j.1471-4159.2001.00104.x

Bibliografisk träff 2001-02-01

The effect of postnatal age on L-2-chloropropionic acid-induced cerebellar granule cell necrosis in the rat.

Lock EA, Gyte A, Duffell S, Wyatt I.

Arch Toxicol · journal article · DOI 10.1007/s002040000194

Bibliografisk träff 2001-02-01

MRI studies of the neurotoxic effects of L-2-chloropropionic acid on rat brain.

Williams RE, Prior M, Bachelard HS, Waterton JC, Checkley D, Lock EA.

Magn Reson Imaging · research support, non-u.s. gov't; journal article · DOI 10.1016/s0730-725x(01)00231-4

Bibliografisk träff 2000-11-01

The absence of cerebellar granule cell necrosis in the mouse following L-2-chloropropionic acid administration.

Lock EA, Gyte A, Duffell S, Wyatt I.

Arch Toxicol · journal article · DOI 10.1007/s002040000160

Bibliografisk träff 2000-05-01

Neurotoxic effect of L-2-chloropropionic acid on primary cultures of rat cerebellar granule cells.

Sturgess NC, Rustad A, Fonnum F, Lock EA.

Arch Toxicol · journal article · DOI 10.1007/s002040050668

Bibliografisk träff 1999-07-01

Biochemical and neurotoxicological effects of L-2-chloropropionic acid on rodent brain.

Williams RE, Jones P, Lock EA, Bachelard HS.

J Neurochem · research support, non-u.s. gov't; journal article · DOI 10.1046/j.1471-4159.1999.0730362.x

Bibliografisk träff 1997-08-01

L-2-chloropropionic acid-induced neurotoxicity in the rat: a valuable model for studying selective neuronal cell death in vivo.

Widdowson PS, Simpson MG, Wyatt I.

Gen Pharmacol · review; journal article · DOI 10.1016/s0306-3623(96)00420-x

Bibliografisk träff 1997-03-01

Ultrastructural pathology and cytochemical investigations of L-2-chloropropionic acid-induced neurointoxication of the rat cerebellum.

Jones HB, Jenkins CR, Bowdler AL, Simpson MG, Lock EA.

Acta Neuropathol · journal article · DOI 10.1007/s004010050610

Bibliografisk träff 1997-02-01

Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.

Widdowson PS, Gyte A, Upton R, Foster J, Coutts CT, Wyatt I.

Toxicol Appl Pharmacol · journal article · DOI 10.1006/taap.1996.7940

Bibliografisk träff 1997-01-01

L-2-chloropropionic acid inhibits glutamate and aspartate release from rat cerebellar slices but does not activate cerebellar NMDA receptors: implications for L-2-chloropropionic acid-induced neurotoxicity.

Widdowson PS, Briggs I, BoSmith RE, Sturgess NC, Rosbottom A, Smith JC, Wyatt I.

Neurotoxicology · comparative study; journal article

Bibliografisk träff 1997-01-01

L-2-Chloropropionic acid metabolism and disposition in male rats: relevance to cerebellar injury.

Wyatt I, Farnworth M, Gyte AJ, Lock EA.

Arch Toxicol · journal article · DOI 10.1007/s002040050443

Bibliografisk träff 1997-01-01

L-2-chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists.

Widdowson PS, Gyte A, Upton R, Smith JC, Pitts M, Moores R, Wyatt I.

Arch Toxicol · comparative study; journal article · DOI 10.1007/s002040050457

Bibliografisk träff 1996-11-01

Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors.

Widdowson PS, Gyte AJ, Upton R, Wyatt I.

Brain Res · comparative study; journal article · DOI 10.1016/s0006-8993(96)00779-2

Bibliografisk träff 1996-09-01

Evidence for mediation of L-2-chloropropionic acid-induced delayed neuronal cell death by activation of a constitutive nitric oxide synthase.

Widdowson PS, Farnworth M, Moore RB, Dunn D, Wyatt I.

Br J Pharmacol · research-article; journal article · DOI 10.1111/j.1476-5381.1996.tb15996.x

Bibliografisk träff 1996-04-01

Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis.

Widdowson PS, Gyte A, Simpson MG, Farnworth M, Dunn D, Moore RB, Wyatt I, Lock EA.

Br J Pharmacol · research-article; journal article · DOI 10.1111/j.1476-5381.1996.tb15351.x

Bibliografisk träff 1996-01-01

L-2-chloropropionic acid-induced neurotoxicity is prevented by MK-801: possible role of NMDA receptors in the neuropathology.

Widdowson PS, Wyatt I, Gyte A, Simpson MG, Lock EA.

Toxicol Appl Pharmacol · journal article · DOI 10.1006/taap.1996.0017

Bibliografisk träff 1996-01-01

Changes in cerebellar amino acid neurotransmitter concentrations and receptors following administration of the neurotoxin L-2-chloropropionic acid.

Widdowson PS, Gyte A, Simpson MG, Wyatt I, Lock EA.

Toxicol Appl Pharmacol · journal article · DOI 10.1006/taap.1996.0006

Bibliografisk träff 1996-01-01

Neuropathological changes in rat brain following oral administration of 2-chloropropionic acid.

Simpson MG, Wyatt I, Jones HB, Gyte AJ, Widdowson PS, Lock EA.

Neurotoxicology · comparative study; journal article

Bibliografisk träff 1996-01-01

The role of glutathione in L-2-chloropropionic acid induced cerebellar granule cell necrosis in the rat.

Wyatt I, Gyte A, Simpson MG, Widdowson PS, Lock EA.

Arch Toxicol · journal article · DOI 10.1007/s002040050333

Bibliografisk träff 1995-01-01

[125I]endothelin binding in rat cerebellum is increased following L-2-chloropropionic-acid-induced granule cell necrosis.

Widdowson PS, Simpson MG, Wyatt I, Lock EA.

Peptides · comparative study; journal article · DOI 10.1016/0196-9781(95)00050-t