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Publikationer i urvalet

16 träffar

Bibliografisk träff 2026-03-26

RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.

Ross SE, Holliday H, Wang E, Zeraati M, Tsoli M, Ziegler DS, Dinger ME.

Cell Death Dis · research-article; journal article · DOI 10.1038/s41419-026-08647-8

Bibliografisk träff 2026-01-21

FB23-2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex.

Jiang Y, Cai H, Zhu Y, Liang J, Li H, Song F, Wang Z, Hou J.

Cancer Sci · research-article; journal article · DOI 10.1111/cas.70322

Bibliografisk träff 2025-07-29

Targeting N6-methyladenosine demethylase FTO overcomes osimertinib resistance by inducing G0/G1 phase arrest in an m6A-dependent manner in lung adenocarcinoma.

Chen J, Hu C, Wu J, Liang Z, Qian J, Chen C, Huang H, Zhu Y, Zhao Y, Li Y.

Biochem Pharmacol · journal article · DOI 10.1016/j.bcp.2025.117198

Bibliografisk träff 2025-07-05

FTO inhibition represses B-cell acute lymphoblastic leukemia progression by inducing nucleolar stress and mitochondrial dysfunction.

Li X, Yang Z, Huang S, Wang J, Wang X, Liang Y, Han H.

Free Radic Biol Med · journal article · DOI 10.1016/j.freeradbiomed.2025.07.004

Bibliografisk träff 2025-04-02

The m6A RNA demethylase FTO promotes radioresistance and stemness maintenance of glioma stem cells.

Zhang J, Li G, Wu R, Shi L, Tian C, Jiang H, Che H, Jiang Y, Jin Z, Yu R, Liu X, Zhang X.

Cell Signal · research support, non-u.s. gov't; journal article · DOI 10.1016/j.cellsig.2025.111782

Bibliografisk träff 2024-11-26

Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.

Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, Masciarelli S, Marchioni M, Giorgis M, Lolli ML, Fornaseri F, Proietti L, Grebien F, Rosignoli S, Paiardini A, Rotili D, Mai A, Bochenkova E, Caflisch A, Fazi F, Fatica A.

ACS Pharmacol Transl Sci · research-article; journal article · DOI 10.1021/acsptsci.4c00533

Bibliografisk träff 2024-06-19

Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression.

Jiang L, Liang R, Luo Q, Chen Z, Song G.

Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bcp.2024.116375

Bibliografisk träff 2024-05-22

Small molecules that regulate the N6-methyladenosine RNA modification as potential anti-cancer agents.

Harrahill NJ, Hadden MK.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116526

Bibliografisk träff 2024-02-15

FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.

He J, Zhao Y, Zhang Y, Zhang Z, Li D, Xu Q.

Cell Signal · research support, non-u.s. gov't; journal article · DOI 10.1016/j.cellsig.2024.111098

Bibliografisk träff 2023-12-22

N6-methyladenosine promotes aberrant redox homeostasis required for arsenic carcinogenesis by controlling the adaptation of key antioxidant enzymes.

Zhao T, Sun D, Long K, Xiong W, Man J, Zhang Q, Zhang Z.

J Hazard Mater · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jhazmat.2023.133329

Bibliografisk träff 2023-10-27

Chemical Inhibitors Targeting the Oncogenic m6A Modifying Proteins.

Huang Y, Xia W, Dong Z, Yang CG.

Acc Chem Res · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.accounts.3c00451

Bibliografisk träff 2023-10-05

Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling.

Liu B, Xia L, Li Y, Jiang S, Yu W, Zhang L, Shao XM, Xu Z, Xiao D.

Hypertension · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/hypertensionaha.123.21766

Bibliografisk träff 2023-10-01

Qiteng Xiaozhuo granules medicated serum inhibits excessive proliferation and promotes apoptosis of human glomerular mesangial cells by targeting fat mass and obesity associated proteins.

Xingxing Z, Tao L, Liangbing W, Junmei S, Jiarong G.

J Tradit Chin Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.19852/j.cnki.jtcm.2023.06.005

Bibliografisk träff 2020-04-15

Recent developments of small molecules targeting RNA m6A modulators.

Gu J, Xu J, You Q, Guo X.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112325

Bibliografisk träff 2019-04-01

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.

Van Der Werf I, Jamieson C.

Cancer Cell · comment; journal article · DOI 10.1016/j.ccell.2019.03.011

Bibliografisk träff 2019-04-01

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG.

Cancer Cell · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ccell.2019.03.006

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Publikationer i urvalet

RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.

FB23-2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex.

Targeting N<sup>6</sup>-methyladenosine demethylase FTO overcomes osimertinib resistance by inducing G0/G1 phase arrest in an m<sup>6</sup>A-dependent manner in lung adenocarcinoma.

FTO inhibition represses B-cell acute lymphoblastic leukemia progression by inducing nucleolar stress and mitochondrial dysfunction.

The m6A RNA demethylase FTO promotes radioresistance and stemness maintenance of glioma stem cells.

Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (<i>h</i>DHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.

Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression.

Small molecules that regulate the N<sup>6</sup>-methyladenosine RNA modification as potential anti-cancer agents.

FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.

N<sup>6</sup>-methyladenosine promotes aberrant redox homeostasis required for arsenic carcinogenesis by controlling the adaptation of key antioxidant enzymes.

Chemical Inhibitors Targeting the Oncogenic m<sup>6</sup>A Modifying Proteins.

Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling.

Qiteng Xiaozhuo granules medicated serum inhibits excessive proliferation and promotes apoptosis of human glomerular mesangial cells by targeting fat mass and obesity associated proteins.

Recent developments of small molecules targeting RNA m<sup>6</sup>A modulators.

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.