The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Glennon RA.
J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.7b00085 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
26 träffarPotential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800771x'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2008.04.030The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.
Parker MA, Kurrasch DM, Nichols DE.
Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2008.02.033Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.
Gallardo-Godoy A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm0493109Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Glennon RA, Bondarev ML, Khorana N, Young R, May JA, Hellberg MR, McLaughlin MA, Sharif NA.
J Med Chem · journal article · DOI 10.1021/jm040082sRing substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.
Peddi S, Roth BL, Glennon RA, Westkaemper RB.
Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0960-894x(03)00504-3Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm030064v1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.
Rangisetty JB, Dukat M, Dowd CS, Herrick-Davis K, DuPre A, Gadepalli S, Teitler M, Kelley CR, Sharif NA, Glennon RA.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm0100739Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.
Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, Nichols DE.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm000491y1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.
Dowd CS, Herrick-Davis K, Egan C, DuPre A, Smith C, Teitler M, Glennon RA.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9906062The frontier orbital phase angles: novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens.
Clare BW.
J Med Chem · journal article · DOI 10.1021/jm980144cDihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.
Monte AP, Marona-Lewicka D, Parker MA, Wainscott DB, Nelson DL, Nichols DE.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960199j1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00051a011Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines.
Glennon RA, Dukat M, el-Bermawy M, Law H, De los Angeles J, Teitler M, King A, Herrick-Davis K.
J Med Chem · journal article · DOI 10.1021/jm00039a004Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.
Glennon RA, Raghupathi R, Bartyzel P, Teitler M, Leonhardt S.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00082a0142,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines.
Nichols DE, Snyder SE, Oberlender R, Johnson MP, Huang XM.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00105a043A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors.
Seggel MR, Yousif MY, Lyon RA, Titeler M, Roth BL, Suba EA, Glennon RA.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00165a023N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Glennon RA, Titeler M, Seggel MR, Lyon RA.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00388a032Central serotonin receptors as targets for drug research.
Glennon RA.
J Med Chem · review; journal article · DOI 10.1021/jm00384a0015-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues.
Glennon RA, McKenney JD, Lyon RA, Titeler M.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00152a005Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.
Glennon RA, Young R, Benington F, Morin RD.
J Med Chem · journal article · DOI 10.1021/jm00352a013Photoelectron spectra of psychotropic drugs. 6. Relationships between the physical properties and pharmacological actions of amphetamine analogues.
Domelsmith LN, Eaton TA, Houk KN, Anderson GM, Glennon RA, Shulgin AT, Castagnoli N, Kollman PA.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00144a009Serotonin receptor affinities of psychoactive phenalkylamine analogues.
Glennon RA, Liebowitz SM, Anderson GM.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00177a017Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.
Glennon RA, Liebowitz SM, Mack EC.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00206a022Structure-activity studies on hallucinogenic amphetamines using molecular connectivity.
Kier LB, Hall LH.
J Med Chem · journal article · DOI 10.1021/jm00222a019