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Publikationer i urvalet

45 träffar

Bibliografisk träff 2021-12-11

Chemotherapeutics for <i>Toxoplasma gondii</i>: Molecular Biotargets, Binding Modes, and Structure-Activity Relationship Investigations.

Wu RZ, Zhou HY, Song JF, Xia QH, Hu W, Mou XD, Li X.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01569

Bibliografisk träff 2019-06-04

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.

Shah K, Queener S, Cody V, Pace J, Gangjee A.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2019.06.004

Bibliografisk träff 2018-04-17

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.

Shah K, Lin X, Queener SF, Cody V, Pace J, Gangjee A.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2018.04.032

Bibliografisk träff 2015-03-14

Recent advances in the chemistry and biology of pyridopyrimidines.

Buron F, Mérour JY, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.ejmech.2015.03.029

Bibliografisk träff 2013-05-21

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.

Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm400086g

Bibliografisk träff 2010-05-01

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature09107

Bibliografisk träff 2010-02-06

Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.

Prado-Prado FJ, García-Mera X, González-Díaz H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.01.068

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2008-09-05

N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.

Gangjee A, Adair OO, Pagley M, Queener SF.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800694g

Bibliografisk träff 2005-06-01

Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.

Chan DC, Fu H, Forsch RA, Queener SF, Rosowsky A.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm0581718

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2004-05-01

Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.

Rosowsky A, Fu H, Chan DC, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030599o

Bibliografisk träff 2004-04-01

Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.

Forsch RA, Queener SF, Rosowsky A.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.bmcl.2003.12.103

Bibliografisk träff 2004-03-01

New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.

Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm030438k

Bibliografisk träff 2003-11-01

Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.

Gangjee A, Adair OO, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030312n

Bibliografisk träff 2003-04-01

Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.

Rosowsky A, Forsch RA, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm020466n

Bibliografisk träff 2002-01-01

Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.

Rosowsky A, Forsch RA, Queener SF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010407u

Bibliografisk träff 2001-07-01

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.

Graffner-Nordberg M, Kolmodin K, Aqvist J, Queener SF, Hallberg A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010856u

Bibliografisk träff 1999-07-01

Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.

Gangjee A, Adair O, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990079m

Bibliografisk träff 1999-03-01

Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.

Rosowsky A, Papoulis AT, Forsch RA, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm980572i

Bibliografisk träff 1998-11-01

6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.

Gangjee A, Zhu Y, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm980206z

Bibliografisk träff 1998-03-01

2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Rosowsky A, Papoulis AT, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970614n

Bibliografisk träff 1997-09-01

Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.

Gangjee A, Vasudevan A, Queener SF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970271t

Bibliografisk träff 1997-09-01

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970055k

Bibliografisk träff 1997-06-01

Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.

Gangjee A, Shi J, Queener SF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960693n

Bibliografisk träff 1997-03-01

Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.

Gangjee A, Mavandadi F, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960717q

Bibliografisk träff 1997-02-01

Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.

Gangjee A, Devraj R, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9606913

Bibliografisk träff 1997-02-01

Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.

Gangjee A, Vasudevan A, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960734f

Bibliografisk träff 1996-04-01

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.

Gangjee A, Zhu Y, Queener SF, Francom P, Broom AD.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950918e