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Publikationer i urvalet

20 träffar

Bibliografisk träff 2018-04-04

Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D<sub>3</sub> receptor ligands with extended functionality for probing the secondary binding pocket.

Omran A, Eslamimehr S, Crider AM, Neumann WL.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.03.084

Bibliografisk träff 2015-11-30

Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease.

Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b01031

Bibliografisk träff 2010-03-01

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

Pettersson F, Pontén H, Waters N, Waters S, Sonesson C.

J Med Chem · journal article · DOI 10.1021/jm901689v

Bibliografisk träff 2005-04-01

CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.

Boeckler F, Ohnmacht U, Lehmann T, Utz W, Hübner H, Gmeiner P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm049269+

Bibliografisk träff 2003-06-01

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.

Cao J, Kulkarni SS, Husbands SM, Bowen WD, Williams W, Kopajtic T, Katz JL, George C, Newman AH.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm030008u

Bibliografisk träff 2002-09-01

Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.

Löber S, Hübner H, Gmeiner P.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(02)00390-6

Bibliografisk träff 2001-01-01

Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.

Macchia B, Cervetto L, Demontis GC, Domiano P, Longoni B, Macchia M, Minutolo F, Orlandini E, Ortore G, Papi C.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00633-8

Bibliografisk träff 1998-12-01

N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.

Cervetto L, Demontis GC, Giannaccini G, Longoni B, Macchia B, Macchia M, Martinelli A, Orlandini E.

J Med Chem · journal article · DOI 10.1021/jm9708700

Bibliografisk träff 1997-12-01

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, Webb MB, Katz AH, Park A, Kang YH, Abou-Gharbia M, Scerni R, Wasik T, Cortes-Burgos L, Spangler T, Brennan JA, Piesla M, Mazandarani H, Cockett MI, Ochalski R, Coupet J, Andree TH.

J Med Chem · journal article · DOI 10.1021/jm9703653

Bibliografisk träff 1995-08-01

On the quantitative structure-activity relationships of meta-substituted (S)-phenylpiperidines, a class of preferential dopamine D2 autoreceptor ligands: modeling of dopamine synthesis and release in vivo by means of partial least squares regression.

Hansson LO, Waters N, Holm S, Sonesson C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00016a015

Bibliografisk träff 1994-08-01

Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.

Sonesson C, Lin CH, Hansson L, Waters N, Svensson K, Carlsson A, Smith MW, Wikström H.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00043a013

Bibliografisk träff 1994-05-01

Molecular similarity, quantitative chirality, and QSAR for chiral drugs.

Seri-Levy A, West S, Richards WG.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00037a025

Bibliografisk träff 1992-08-01

Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.

Perrone R, Berardi F, Leopoldo M, Tortorella V, Lograno MD, Daniele E, Govoni S.

J Med Chem · journal article · DOI 10.1021/jm00094a019

Bibliografisk träff 1990-03-01

Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.

Liljefors T, Bøgesø KP, Hyttel J, Wikström H, Svensson K, Carlsson A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00165a020

Bibliografisk träff 1987-12-01

N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.

Wikström H, Andersson B, Elebring T, Svensson K, Carlsson A, Largent B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00395a002

Bibliografisk träff 1987-12-01

Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.

Van de Waterbeemd H, el Tayar N, Testa B, Wikström H, Largent B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00395a003

Bibliografisk träff 1987-01-01

Indolizidine and quinolizidine derivatives of the dopamine autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP).

Bøgesø KP, Arnt J, Lundmark M, Sundell S.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00384a024

Bibliografisk träff 1986-10-01

Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics.

Rollema H, Mastebroek D, Wikström H, Svensson K, Carlsson A, Sundell S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00160a016

Bibliografisk träff 1986-10-01

A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series.

Liljefors T, Wikström H.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00160a017

Bibliografisk träff 1984-08-01

Resolved 3-(3-hydroxyphenyl)-N-n-propylpiperidine and its analogues: central dopamine receptor activity.

Wikström H, Sanchez D, Lindberg P, Hacksell U, Arvidsson LE, Johansson AM, Thorberg SO, Nilsson JL, Svensson K, Hjorth S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00374a016