Designed multiple ligands. An emerging drug discovery paradigm.
Morphy R, Rankovic Z.
J Med Chem · review; journal article · DOI 10.1021/jm058225d PUBLIKATIONSREGISTRET
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13 träffarThromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.
Dickinson RP, Dack KN, Long CJ, Steele J.
J Med Chem · journal article · DOI 10.1021/jm9702793Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.
Ohshima E, Sato H, Obase H, Miki I, Ishii A, Kawakage M, Shirakura S, Karasawa A, Kubo K.
J Med Chem · journal article · DOI 10.1021/jm00063a011Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
Tomiyama T, Yokota M, Wakabayashi S, Kosakai K, Yanagisawa T.
J Med Chem · journal article · DOI 10.1021/jm00059a001Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists.
Nicolaï E, Goyard J, Benchetrit T, Teulon JM, Caussade F, Virone A, Delchambre C, Cloarec A.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00061a008Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1.
Ohshima E, Takami H, Harakawa H, Sato H, Obase H, Miki I, Ishii A, Ishii H, Sasaki Y, Ohmori K.
J Med Chem · journal article · DOI 10.1021/jm00055a013Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds.
Main AJ, Goldstein R, Cohen DS, Furness P, Lee W.
J Med Chem · journal article · DOI 10.1021/jm00101a013Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1.
Ohshima E, Takami H, Sato H, Obase H, Miki I, Ishii A, Karasawa A, Kubo K.
J Med Chem · journal article · DOI 10.1021/jm00096a016FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor antagonist S-145 and related compounds. 3. Conformation and activity of S-145 analogues.
Takasuka M, Yamakawa M, Ohtani M.
J Med Chem · journal article · DOI 10.1021/jm00110a020Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists.
Tomiyama T, Wakabayashi S, Kosakai K, Yokota M.
J Med Chem · journal article · DOI 10.1021/jm00171a0049,11-epoxy-9-homoprosta-5-enoic acid analogues as thromboxane A2 receptor antagonists.
Das J, Hall SE, Nakane M, Haslanger MF, Reid JA, Garber D, Truc VC, Harris DN, Hedberg A, Ogletree ML.
J Med Chem · journal article · DOI 10.1021/jm00168a032Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (+-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid.
Ohtani M, Narisada M.
J Med Chem · journal article · DOI 10.1021/jm00165a022Synthesis and pharmacological evaluation of 5,6-exo-epoxy-7-oxabicyclo[2.2.1]heptane derivatives.
Das J, Vu T, Harris DN, Ogletree ML.
J Med Chem · journal article · DOI 10.1021/jm00400a007