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Publikationer i urvalet

27 träffar

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2000-11-01

Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.

Hartmann RW, Hector M, Haidar S, Ehmer PB, Reichert W, Jose J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm001008m

Bibliografisk träff 2000-11-01

Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).

Hartmann RW, Hector M, Wachall BG, Palusczak A, Palzer M, Huch V, Veith M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm991070n

Bibliografisk träff 2000-05-01

1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.

Jacobs C, Frotscher M, Dannhardt G, Hartmann RW.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm991180u

Bibliografisk träff 1999-09-01

Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.

Liao YH, Houghton PJ, Hoult JR.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np990092+

Bibliografisk träff 1995-05-01

A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-thromboxane receptor antagonists and -thromboxane synthase inhibitors.

Ackerley N, Brewster AG, Brown GR, Clarke DS, Foubister AJ, Griffin SJ, Hudson JA, Smithers MJ, Whittamore PR.

J Med Chem · journal article · DOI 10.1021/jm00010a005

Bibliografisk träff 1993-10-01

Tröger's base. An alternate synthesis and a structural analog with thromboxane A2 synthetase inhibitory activity.

Johnson RA, Gorman RR, Wnuk RJ, Crittenden NJ, Aiken JW.

J Med Chem · journal article · DOI 10.1021/jm00073a023

Bibliografisk träff 1993-10-01

Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition.

Cozzi P, Carganico G, Fusar D, Grossoni M, Menichincheri M, Pinciroli V, Tonani R, Vaghi F, Salvati P.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00072a017

Bibliografisk träff 1991-06-01

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids.

Bhagwat SS, Gude C, Cohen DS, Lee W, Furness P, Clarke FH.

J Med Chem · journal article · DOI 10.1021/jm00110a006

Bibliografisk träff 1990-02-01

Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines.

Archibald JL, Bradley G, Opalko A, Ward TJ, White JC, Ennis C, Shepperson NB.

J Med Chem · journal article · DOI 10.1021/jm00164a028

Bibliografisk träff 1989-08-01

3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.

Cohen N, Weber G, Banner BL, Lopresti RJ, Schaer B, Focella A, Zenchoff GB, Chiu AM, Todaro L, O'Donnell M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00128a028

Bibliografisk träff 1989-06-01

Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives.

Amemiya Y, Terada A, Wachi K, Miyazawa H, Hatakeyama N, Matsuda K, Oshima T.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00126a020

Bibliografisk träff 1989-06-01

Thromboxane A2 synthetase inhibitors. 2. Syntheses and activities of tetrahydronaphthalene and indan derivatives.

Kanao M, Watanabe Y, Kimura Y, Saegusa J, Yamamoto K, Kanno H, Kanaya N, Kubo H, Ashida S, Ishikawa F.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00126a031

Bibliografisk träff 1989-04-01

[(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.

Martinez GR, Walker KA, Hirschfeld DR, Maloney PJ, Yang DS, Rosenkranz RP.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00124a027

Bibliografisk träff 1988-09-01

Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1] hept-2-exo-yl]heptenoic acid.

Narisada M, Ohtani M, Watanabe F, Uchida K, Arita H, Doteuchi M, Hanasaki K, Kakushi H, Otani K, Hara S.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00117a028

Bibliografisk träff 1987-12-01

Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones.

Wright WB, Tomcufcik AS, Chan PS, Marsico JW, Press JB.

J Med Chem · journal article · DOI 10.1021/jm00395a016

Bibliografisk träff 1987-10-01

Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids.

Manley PW, Tuffin DP, Allanson NM, Buckle PE, Lad N, Lai SM, Lunt DO, Porter RA, Wade PJ.

J Med Chem · journal article · DOI 10.1021/jm00393a022

Bibliografisk träff 1987-09-01

Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors.

Manley PW, Allanson NM, Booth RF, Buckle PE, Kuzniar EJ, Lad N, Lai SM, Lunt DO, Tuffin DP.

J Med Chem · journal article · DOI 10.1021/jm00392a011

Bibliografisk träff 1987-06-01

Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors.

Press JB, Wright WB, Chan PS, Haug MF, Marsico JW, Tomcufcik AS.

J Med Chem · journal article · DOI 10.1021/jm00389a013

Bibliografisk träff 1987-01-01

N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.

Tilley JW, Levitan P, Lind J, Welton AF, Crowley HJ, Tobias LD, O'Donnell M.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00384a031

Bibliografisk träff 1986-09-01

Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene.

Cross PE, Dickinson RP, Parry MJ, Randall MJ.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00159a013

Bibliografisk träff 1986-09-01

Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids.

Cross PE, Dickinson RP, Parry MJ, Randall MJ.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00159a012

Bibliografisk träff 1986-08-01

Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids.

Johnson RA, Nidy EG, Aiken JW, Crittenden NJ, Gorman RR.

J Med Chem · journal article · DOI 10.1021/jm00158a024

Bibliografisk träff 1986-05-01

Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.

Press JB, Wright WB, Chan PS, Marsico JW, Haug MF, Tauber J, Tomcufcik AS.

J Med Chem · journal article · DOI 10.1021/jm00155a036

Bibliografisk träff 1986-04-01

Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides.

Wright WB, Press JB, Chan PS, Marsico JW, Haug MF, Lucas J, Tauber J, Tomcufcik AS.

J Med Chem · journal article · DOI 10.1021/jm00154a017

Bibliografisk träff 1986-03-01

Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.

Cross PE, Dickinson RP, Parry MJ, Randall MJ.

J Med Chem · journal article · DOI 10.1021/jm00153a007

Bibliografisk träff 1985-10-01

Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.

Cross PE, Dickinson RP, Parry MJ, Randall MJ.

J Med Chem · journal article · DOI 10.1021/jm00148a009