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Publikationer i urvalet

15 träffar

Bibliografisk träff 2016-05-28

Development of novel NK3 receptor antagonists with reduced environmental impact.

Yamamoto K, Okazaki S, Ohno H, Matsuda F, Ohkura S, Maeda K, Fujii N, Oishi S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.05.054

Bibliografisk träff 2015-03-18

Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).

Hoveyda HR, Fraser GL, Roy MO, Dutheuil G, Batt F, El Bousmaqui M, Korac J, Lenoir F, Lapin A, Noël S, Blanc S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm5017413

Bibliografisk träff 2013-12-15

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.

Hanessian S, Babonneau V, Boyer N, Mannoury la Cour C, Millan MJ, De Nanteuil G.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2013.12.033

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-05-22

Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.

Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P.

J Med Chem · journal article · DOI 10.1021/jm2017072

Bibliografisk träff 2011-10-12

3D-Quantitative structure-activity relationship and docking studies of the tachykinin NK3 receptor.

Geldenhuys WJ, Simmons MA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.10.014

Bibliografisk träff 2011-02-13

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.

Hoveyda HR, Roy MO, Blanc S, Noël S, Salvino JM, Ator MA, Fraser G.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.02.033

Bibliografisk träff 2010-11-03

Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor.

Geldenhuys WJ, Kuzenko SR, Simmons MA.

J Med Chem · journal article · DOI 10.1021/jm1010012

Bibliografisk träff 2009-11-01

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

Malherbe P, Kratzeisen C, Marcuz A, Zenner MT, Nettekoven MH, Ratni H, Wettstein JG, Bissantz C.

J Med Chem · journal article · DOI 10.1021/jm900948q

Bibliografisk träff 2008-12-07

New quinoline NK3 receptor antagonists with CNS activity.

Smith PW, Wyman PA, Lovell P, Goodacre C, Serafinowska HT, Vong A, Harrington F, Flynn S, Bradley DM, Porter R, Coggon S, Murkitt G, Searle K, Thomas DR, Watson JM, Martin W, Wu Z, Dawson LA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.12.005

Bibliografisk träff 2006-09-06

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

Elliott JM, Carling RW, Chambers M, Chicchi GG, Hutson PH, Jones AB, MacLeod A, Marwood R, Meneses-Lorente G, Mezzogori E, Murray F, Rigby M, Royo I, Russell MG, Sohal B, Tsao KL, Williams B.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.08.086

Bibliografisk träff 2001-05-01

Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.

Blaney FE, Raveglia LF, Artico M, Cavagnera S, Dartois C, Farina C, Grugni M, Gagliardi S, Luttmann MA, Martinelli M, Nadler GM, Parini C, Petrillo P, Sarau HM, Scheideler MA, Hay DW, Giardina GA.

J Med Chem · journal article · DOI 10.1021/jm000501v

Bibliografisk träff 2000-06-01

Predicting blood-brain barrier permeation from three-dimensional molecular structure.

Crivori P, Cruciani G, Carrupt PA, Testa B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm990968+

Bibliografisk träff 1999-03-01

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).

Giardina GA, Raveglia LF, Grugni M, Sarau HM, Farina C, Medhurst AD, Graziani D, Schmidt DB, Rigolio R, Luttmann M, Cavagnera S, Foley JJ, Vecchietti V, Hay DW.

J Med Chem · journal article · DOI 10.1021/jm980633c

Bibliografisk träff 1996-06-01

2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

Giardina GA, Sarau HM, Farina C, Medhurst AD, Grugni M, Foley JJ, Raveglia LF, Schmidt DB, Rigolio R, Vassallo M, Vecchietti V, Hay DW.

J Med Chem · comparative study; journal article · DOI 10.1021/jm9602423