Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes.
Torikai K, Otsuka Y, Nishimura M, Sumida M, Kawai T, Sekiguchi K, Ueda I.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2008.04.009 PUBLIKATIONSREGISTRET
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50 träffarSynthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate.
Edsall AB, Agoston GE, Treston AM, Plum SM, McClanahan RH, Lu TS, Song W, Cushman M.
J Med Chem · journal article · DOI 10.1021/jm070639eHologram QSAR model for the prediction of human oral bioavailability.
Moda TL, Montanari CA, Andricopulo AD.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.08.060Synthesis and anticancer activity of a novel class of flavonoids: 2,4-diarylchromane[4,3-d]-delta(1,9b)-1,2,3-thiadiazolines.
Ying H, Hu Y, He Q, Li R, Yang B.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2006.10.004Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.
Bi Y, Xu J, Wu X, Ye W, Yuan S, Zhang L.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.09.096Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus.
Zhong S, Huang M, Yang X, Liang L, Wang Y, Romkes M, Duan W, Chan E, Zhou SF.
Br J Clin Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1365-2125.2006.02690.xNovel class of cyclophosphamide prodrug: cyclophosphamide spiropiperaziniums (CPSP).
Sun Q, Li RT, Guo W, Cui JR, Cheng TM, Ge ZM.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.04.049A novel immunostimulator, N-[alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen.
Yang HZ, Xu S, Liao XY, Zhang SD, Liang ZL, Liu BH, Bai JY, Jiang C, Ding J, Cheng GF, Liu G.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm0493313Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Jolivette LJ, Ward KW.
J Pharm Sci · comparative study; journal article · DOI 10.1002/jps.20373Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.
Curr Drug Discov Technol · journal article · DOI 10.2174/1570163043334794[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Suomalainen P, Johans C, Söderlund T, Kinnunen PK.
J Med Chem · journal article · DOI 10.1021/jm0309001CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity, and preliminary toxicity study.
Wang Y, Li L, Ye W, Tian Z, Jiang W, Wang H, Wright SC, Larrick JW.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0203433Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency.
Haubitz M, Bohnenstengel F, Brunkhorst R, Schwab M, Hofmann U, Busse D.
Kidney Int · research support, non-u.s. gov't; journal article · DOI 10.1046/j.1523-1755.2002.00279.xQuantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW.
Chem Res Toxicol · journal article · DOI 10.1021/tx010125xDesign, synthesis, and biological evaluation of analogues of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Hazeldine ST, Polin L, Kushner J, Paluch J, White K, Edelstein M, Palomino E, Corbett TH, Horwitz JP.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm0005149QSAR model for drug human oral bioavailability.
Yoshida F, Topliss JG.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.
Wang Y, Yuan H, Ye W, Wright SC, Wang H, Larrick JW.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990514cSynthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
Perni RB, Wentland MP, Huang JI, Powles RG, Aldous S, Klingbeil KM, Peverly AD, Robinson RG, Corbett TH, Jones JL, Mattes KC, Rake JB, Coughlin SA.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9708083N3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide.
Moon KY, Kwon CH.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00287-xChemically stable N-methyl-4-(alkylthio)cyclophosphamide derivatives as prodrugs of 4-hydroxycyclophosphamide.
Moon KY, Shirota FN, Baturay N, Kwon CH.
J Med Chem · journal article · DOI 10.1021/jm00005a012Chemical and biological evaluation of hydrolysis products of cyclophosphamide.
Gilard V, Martino R, Malet-Martino MC, Kutscher B, Müller A, Niemeyer U, Pohl J, Polymeropoulos EE.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00049a018Novel anticancer prodrugs of butyric acid. 2.
Nudelman A, Ruse M, Aviram A, Rabizadeh E, Shaklai M, Zimrah Y, Rephaeli A.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00082a009Bis basic substituted diaminobenzobisthiazoles as potential antiarthritic agents.
Cullen E, Becker R, Freter K, LeClerq T, Possanza G, Wong HC.
J Med Chem · journal article · DOI 10.1021/jm00080a022Synthesis and antitumor properties of activated cyclophosphamide analogues.
Borch RF, Canute GW.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00114a013N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide. A novel, systemically active antitumor agent effective against 3LL Lewis lung carcinoma.
Schnur RC, Fliri AF, Kajiji S, Pollack VA.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00107a007Chemically stable, lipophilic prodrugs of phosphoramide mustard as potential anticancer agents.
Kwon CH, Moon KY, Baturay N, Shirota FN.
J Med Chem · journal article · DOI 10.1021/jm00106a018Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies.
Wang YQ, Farquhar D.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00105a030Methylsulfamic acid esters. A new chemical class of oral antiarthritic agents.
Walsh DA, Lo YS, Shamblee DA, Welstead WJ, Nolan JC, Graff G.
J Med Chem · journal article · DOI 10.1021/jm00170a003Structure-activity relationships of antineoplastic agents in multidrug resistance.
Selassie CD, Hansch C, Khwaja TA.
J Med Chem · journal article · DOI 10.1021/jm00169a014