An insight into the multifunctional role of ghrelin and structure activity relationship studies of ghrelin receptor ligands with clinical trials.
Bukhari SNA.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114308 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
19 träffarIdentification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.
Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J, Larsson J, Sivars U, Hultin L, Andersson U, Sanganee HJ, Stenvall K, Leidvik B, Gedda K, Jinton L, Rydén Landergren M, Karabelas K.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.8b00322Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffold.
Pellegrino S, Ruscica M, Magni P, Vistoli G, Gelmi ML.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.06.006Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective.
Bornot A, Bauer U, Brown A, Firth M, Hellawell C, Engkvist O.
J Med Chem · journal article · DOI 10.1021/jm301653fHighly potent growth hormone secretagogues.
Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.04.050Modeling of human ghrelin receptor (hGHS-R1a) in its close state and validation by molecular docking.
Pedretti A, Vistoli G.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2007.01.057[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2Recognition of privileged structures by G-protein coupled receptors.
Bondensgaard K, Ankersen M, Thøgersen H, Hansen BS, Wulff BS, Bywater RP.
J Med Chem · journal article · DOI 10.1021/jm0309452Substituted bridged phenyl piperidines: orally active growth hormone secretagogues.
Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(03)00261-0New active series of growth hormone secretagogues.
Guerlavais V, Boeglin D, Mousseaux D, Oiry C, Heitz A, Deghenghi R, Locatelli V, Torsello A, Ghé C, Catapano F, Muccioli G, Galleyrand JC, Fehrentz JA, Martinez J.
J Med Chem · journal article · DOI 10.1021/jm020985q2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.
Patchett AA.
J Med Chem · historical article; address; biography; portrait · DOI 10.1021/jm020424zOxindole derivatives as orally active potent growth hormone secretagogues.
Tokunaga T, Hume WE, Umezome T, Okazaki K, Ueki Y, Kumagai K, Hourai S, Nagamine J, Seki H, Taiji M, Noguchi H, Nagata R.
J Med Chem · journal article · DOI 10.1021/jm0103763Rational design, discovery, and synthesis of a novel series of potent growth hormone secretagogues.
Huang P, Loew GH, Funamizu H, Mimura M, Ishiyama N, Hayashida M, Okuno T, Shimada O, Okuyama A, Ikegami S, Nakano J, Inoguchi K.
J Med Chem · journal article · DOI 10.1021/jm010207iHighly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin.
Hansen TK, Ankersen M, Raun K, Hansen BS.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00345-6Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.
Palucki BL, Feighner SD, Pong S, McKee KK, Hreniuk DL, Tan C, Howard AD, Van der Ploeg LH, Patchett AA, Nargund RP.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00324-9Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.
Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP.
Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/s0960-894x(99)00584-3Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential.
Nargund RP, Patchett AA, Bach MA, Murphy MG, Smith RG.
J Med Chem · review; journal article · DOI 10.1021/jm970342oPotent 3-spiropiperidine growth hormone secretagogues.
Yang L, Morriello G, Prendergast K, Cheng K, Jacks T, Chan WW, Schleim KD, Smith RG, Patchett AA.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(97)10199-8Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor.
Dean DC, Nargund RP, Pong SS, Chaung LY, Griffin P, Melillo DG, Ellsworth RL, Van der Ploeg LH, Patchett AA, Smith RG.
J Med Chem · journal article · DOI 10.1021/jm960054c