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Publikationer i urvalet

35 träffar

Bibliografisk träff 2024-05-24

Cyanomethylquinolones as a New Class of Potential Multitargeting Broad-Spectrum Antibacterial Agents.

Tan YM, Zhang J, Wei YJ, Hu YG, Li SR, Zhang SL, Zhou CH.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.4c00238

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-12-30

Discovery of benzopyridone cyanoacetates as new type of potential broad-spectrum antibacterial candidates.

Zhang J, Tan YM, Li SR, Battini N, Zhang SL, Lin JM, Zhou CH.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.116107

Bibliografisk träff 2023-12-16

Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy.

Dar A, Godara P, Prusty D, Bashir M.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.116056

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2022-02-07

Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens.

Yang X, Sun H, Maddili SK, Li S, Yang RG, Zhou CH.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114188

Bibliografisk träff 2019-07-02

Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus.

Li ZZ, Tangadanchu VKR, Battini N, Bheemanaboina RRY, Zang ZL, Zhang SL, Zhou CH.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.06.093

Bibliografisk träff 2019-06-28

Quinolone antibiotics.

Pham TDM, Ziora ZM, Blaskovich MAT.

Medchemcomm · review-article; review; journal article · DOI 10.1039/c9md00120d

Bibliografisk träff 2019-06-25

Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.

Zhang J, Ba Y, Wang S, Yang H, Hou X, Xu Z.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.06.068

Bibliografisk träff 2018-11-28

Design, synthesis, biological evaluation, structure-activity relationship, and toxicity of clinafloxacin-azole conjugates as novel antitubercular agents.

Liu J, Ren Z, Fan L, Wei J, Tang X, Xu X, Yang D.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.11.035

Bibliografisk träff 2018-09-01

Recent developments of quinolone-based derivatives and their activities against Escherichia coli.

Gao F, Wang P, Yang H, Miao Q, Ma L, Lu G.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.08.095

Bibliografisk träff 2018-08-27

Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA).

Gao C, Fan YL, Zhao F, Ren QC, Wu X, Chang L, Gao F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.08.061

Bibliografisk träff 2018-01-16

Antiplasmodial and antimalarial activities of quinolone derivatives: An overview.

Fan YL, Cheng XW, Wu JB, Liu M, Zhang FZ, Xu Z, Feng LS.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.01.039

Bibliografisk träff 2016-01-30

Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents.

Zhang L, Addla D, Ponmani J, Wang A, Xie D, Wang YN, Zhang SL, Geng RX, Cai GX, Li S, Zhou CH.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2016.01.052

Bibliografisk träff 2015-06-16

Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents.

Zhang L, Kumar KV, Geng RX, Zhou CH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.06.041

Bibliografisk träff 2014-03-17

Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents.

Zhou FW, Lei HS, Fan L, Jiang L, Liu J, Peng XM, Xu XR, Chen L, Zhou CH, Zou YY, Liu CP, He ZQ, Yang DC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.03.010

Bibliografisk träff 2014-03-06

Emergence of pyrido quinoxalines as new family of antimalarial agents.

Chandra Shekhar A, Shanthan Rao P, Narsaiah B, Allanki AD, Sijwali PS.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.03.010

Bibliografisk träff 2013-05-16

Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin.

Zhang L, Chang JJ, Zhang SL, Damu GL, Geng RX, Zhou CH.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.05.007

Bibliografisk träff 2012-07-23

Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents.

Wang Y, Damu GL, Lv JS, Geng RX, Yang DC, Zhou CH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.07.064

Bibliografisk träff 2011-04-07

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.038778

Bibliografisk träff 2010-09-15

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Ekins S, Williams AJ, Xu JJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.035113

Bibliografisk träff 2010-07-01

Developing structure-activity relationships for the prediction of hepatotoxicity.

Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ.

Chem Res Toxicol · journal article · DOI 10.1021/tx1000865

Bibliografisk träff 2010-02-01

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.

J Med Chem · journal article · DOI 10.1021/jm901371v

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-05-06

Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.

Asahina Y, Takei M, Kimura T, Fukuda Y.

J Med Chem · journal article · DOI 10.1021/jm701428b

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2008-04-14

Activity of pradofloxacin against Porphyromonas and Prevotella spp. Implicated in periodontal disease in dogs: susceptibility test data from a European multicenter study.

Stephan B, Greife HA, Pridmore A, Silley P.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; multicenter study; journal article · DOI 10.1128/aac.00019-08

Bibliografisk träff 2007-02-26

Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones.

Matrat S, Petrella S, Cambau E, Sougakoff W, Jarlier V, Aubry A.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01282-06

Bibliografisk träff 2003-08-01

Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.

Hu XE, Kim NK, Gray JL, Almstead JI, Seibel WL, Ledoussal B.

J Med Chem · journal article · DOI 10.1021/jm030272n

Bibliografisk träff 2000-03-01

Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods.

Jaén-Oltra J, Salabert-Salvador MT, García-March FJ, Pérez-Giménez F, Tomás-Vert F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm980448z