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Publikationer i urvalet

13 träffar

Bibliografisk träff 2023-03-03

Identification and in silicon binding study of a novel NR2B selective NMDAR antagonist.

Yang C, Wang H, Yang J, Zhang Y, Qin F, He Y, Liu J, Ma C, Cheng M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2023.129213

Bibliografisk träff 2013-03-27

Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Trippier PC, Jansen Labby K, Hawker DD, Mataka JJ, Silverman RB.

J Med Chem · research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm3015926

Bibliografisk träff 2011-04-08

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Brown DG, Maier DL, Sylvester MA, Hoerter TN, Menhaji-Klotz E, Lasota CC, Hirata LT, Wilkins DE, Scott CW, Trivedi S, Chen T, McCarthy DJ, Maciag CM, Sutton EJ, Cumberledge J, Mathisen D, Roberts J, Gupta A, Liu F, Elmore CS, Alhambra C, Krumrine JR, Wang X, Ciaccio PJ, Wood MW, Campbell JB, Johansson MJ, Xia J, Wen X, Jiang J, Wang X, Peng Z, Hu T, Wang J.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.03.117

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2007-08-15

Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.

Kawai M, Ando K, Matsumoto Y, Sakurada I, Hirota M, Nakamura H, Ohta A, Sudo M, Hattori K, Takashima T, Hizue M, Watanabe S, Fujita I, Mizutani M, Kawamura M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.08.014

Bibliografisk träff 2007-02-10

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

Borza I, Bozó E, Barta-Szalai G, Kiss C, Tárkányi G, Demeter A, Gáti T, Háda V, Kolok S, Gere A, Fodor L, Nagy J, Galgóczy K, Magdó I, Agai B, Fetter J, Bertha F, Keserü GM, Horváth C, Farkas S, Greiner I, Domány G.

J Med Chem · journal article · DOI 10.1021/jm060420k

Bibliografisk träff 2004-08-01

Oxamides as novel NR2B selective NMDA receptor antagonists.

Barta-Szalai G, Borza I, Bozó E, Kiss C, Agai B, Proszenyák A, Keseru GM, Gere A, Kolok S, Galgóczy K, Horváth C, Farkas S, Domány G.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.05.053

Bibliografisk träff 2003-03-01

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

Büttelmann B, Alanine A, Bourson A, Gill R, Heitz MP, Mutel V, Pinard E, Trube G, Wyler R.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(03)00007-6

Bibliografisk träff 2003-02-01

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

Curtis NR, Diggle HJ, Kulagowski JJ, London C, Grimwood S, Hutson PH, Murray F, Richards P, Macaulay A, Wafford KA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)01060-0

Bibliografisk träff 1999-08-01

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.

Tamiz AP, Cai SX, Zhou ZL, Yuen PW, Schelkun RM, Whittemore ER, Weber E, Woodward RM, Keana JF.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm990199u

Bibliografisk träff 1998-03-01

(3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol.

Butler TW, Blake JF, Bordner J, Butler P, Chenard BL, Collins MA, DeCosta D, Ducat MJ, Eisenhard ME, Menniti FS, Pagnozzi MJ, Sands SB, Segelstein BE, Volberg W, White WF, Zhao D.

J Med Chem · journal article · DOI 10.1021/jm9707986

Bibliografisk träff 1995-08-01

(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.

Chenard BL, Bordner J, Butler TW, Chambers LK, Collins MA, De Costa DL, Ducat MF, Dumont ML, Fox CB, Mena EE.

J Med Chem · journal article · DOI 10.1021/jm00016a017