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Publikationer i urvalet

28 träffar

Bibliografisk träff 2024-07-17

7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication.

Chakrasali P, Hwang D, Lee JY, Jung E, Lee HL, Reneesh A, Skarka A, Musilek K, Nguyen NH, Shin JS, Jung YS.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116690

Bibliografisk träff 2024-03-12

4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections.

Barbieri F, Carlen V, Martina MG, Sannio F, Cancade S, Perini C, Restori M, Crespan E, Maga G, Docquier JD, Cagno V, Radi M.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00686g

Bibliografisk träff 2024-02-16

Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents.

Gadali KE, Rafya M, El Mansouri AE, Maatallah M, Vanderlee A, Mehdi A, Neyts J, Jochmans D, De Jonghe S, Benkhalti F, Sanghvi YS, Taourirte M, Lazrek HB.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116235

Bibliografisk träff 2023-12-21

Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents.

G Vishakantegowda A, Hwang D, Chakrasali P, Jung E, Lee JY, Shin JS, Jung YS.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00630a

Bibliografisk träff 2023-08-28

Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.

Li X, Song Y.

Eur J Med Chem · research-article; review; journal article · DOI 10.1016/j.ejmech.2023.115772

Bibliografisk träff 2022-11-24

Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71.

Salerno M, Varricchio C, Bevilacqua F, Jochmans D, Neyts J, Brancale A, Ferla S, Bassetto M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114942

Bibliografisk träff 2021-02-18

Pyridones in drug discovery: Recent advances.

Zhang Y, Pike A.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2021.127849

Bibliografisk träff 2020-11-06

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.

Amin SA, Banerjee S, Ghosh K, Gayen S, Jha T.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; review; journal article · DOI 10.1016/j.bmc.2020.115860

Bibliografisk träff 2019-06-27

Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease.

Ma Y, Li L, He S, Shang C, Sun Y, Liu N, Meek TD, Wang Y, Shang L.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b00387

Bibliografisk träff 2019-01-24

Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects.

Huh J, Song JH, Kim SR, Cho HM, Ko HJ, Yang H, Sung SH.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.8b00590

Bibliografisk träff 2018-11-08

4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease.

Ma Y, Shang C, Yang P, Li L, Zhai Y, Yin Z, Wang B, Shang L.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01335

Bibliografisk träff 2017-06-15

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.

Kim J, Jung YK, Kim C, Shin JS, Scheers E, Lee JY, Han SB, Lee CK, Neyts J, Ha JD, Jung YS.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b00175

Bibliografisk träff 2016-10-11

Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.

Ma GH, Ye Y, Zhang D, Xu X, Si P, Peng JL, Xiao YL, Cao RY, Yin YL, Chen J, Zhao LX, Zhou Y, Zhong W, Liu H, Luo XM, Chen LL, Shen X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.10.019

Bibliografisk träff 2016-05-24

Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease.

Kawatkar SP, Gagnon M, Hoesch V, Tiong-Yip C, Johnson K, Ek M, Nilsson E, Lister T, Olsson L, Patel J, Yu Q.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.05.066

Bibliografisk träff 2016-05-14

Design, synthesis, and biological evaluation of anti-EV71 agents.

Li P, Yang B, Hao F, Wang P, He H, Huang L, Zhang X, Zhang S, Peng X, Yin K, Hu J, Chen X, Gu Z, Wang L, Shen L, Hu G, Li N, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Zhang L, Cai Q, Lin T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.05.036

Bibliografisk träff 2015-11-25

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease.

Zhai Y, Zhao X, Cui Z, Wang M, Wang Y, Li L, Sun Q, Yang X, Zeng D, Liu Y, Sun Y, Lou Z, Shang L, Yin Z.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b01013

Bibliografisk träff 2015-11-02

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

Yan W, Qing J, Mei H, Nong J, Huang J, Zhu J, Jiang H, Liu L, Zhang L, Li J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.11.002

Bibliografisk träff 2015-08-17

Recent Advances in the Discovery of Norovirus Therapeutics.

Kim Y, Galasiti Kankanamalage AC, Chang KO, Groutas WC.

J Med Chem · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b00762

Bibliografisk träff 2012-02-13

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.

Feil SC, Hamilton S, Krippner GY, Lin B, Luttick A, McConnell DB, Nearn R, Parker MW, Ryan J, Stanislawski PC, Tucker SP, Watson KG, Morton CJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml2002955

Bibliografisk träff 2008-11-17

Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer.

Tsai MT, Cheng YH, Liu YN, Liao NC, Lu WW, Kung SH.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00841-08

Bibliografisk träff 2008-06-13

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.

Kuo CJ, Shie JJ, Fang JM, Yen GR, Hsu JT, Liu HG, Tseng SN, Chang SC, Lee CY, Shih SR, Liang PH.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmc.2008.06.015

Bibliografisk träff 2007-12-23

New anti-viral drugs for the treatment of the common cold.

Maugeri C, Alisi MA, Apicella C, Cellai L, Dragone P, Fioravanzo E, Florio S, Furlotti G, Mangano G, Ombrato R, Luisi R, Pompei R, Rincicotti V, Russo V, Vitiello M, Cazzolla N.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2007.12.030

Bibliografisk träff 2007-10-01

In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.

Binford SL, Weady PT, Maldonado F, Brothers MA, Matthews DA, Patick AK.

Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00905-07

Bibliografisk träff 2005-10-01

Pharmacophore modeling, docking, and principal component analysis based clustering: combined computer-assisted approaches to identify new inhibitors of the human rhinovirus coat protein.

Steindl TM, Crump CE, Hayden FG, Langer T.

J Med Chem · journal article · DOI 10.1021/jm050343d

Bibliografisk träff 2004-07-01

Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase.

Jain RP, Vederas JC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.05.021

Bibliografisk träff 2001-10-01

Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.

Webber SE, Marakovits JT, Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Srinivasan B, Moran T, Ford CE, Brothers MA, Harr JE, Meador JW, Ferre RA, Worland ST.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00542-x

Bibliografisk träff 2000-02-01

Protease inhibitors: current status and future prospects.

Leung D, Abbenante G, Fairlie DP.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm990412m

Bibliografisk träff 1999-04-01

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.

Dragovich PS, Prins TJ, Zhou R, Webber SE, Marakovits JT, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Ford CE, Burke BJ, Rejto PA, Hendrickson TF, Tuntland T, Brown EL, Meador JW, Ferre RA, Harr JE, Kosa MB, Worland ST.

J Med Chem · journal article · DOI 10.1021/jm9805384