Insights of synthetic analogues of anti-leprosy agents.
Bera S, Mondal D.
Bioorg Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmc.2019.04.032 PUBLIKATIONSREGISTRET
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Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature09107Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Evans CA, Jolivette LJ, Nagilla R, Ward KW.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.105.006619Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Rosowsky A, Fu H, Chan DC, Queener SF.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030599oInhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
Rosowsky A, Forsch RA, Queener SF.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010407uAdaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Loukas YL.
J Med Chem · comparative study; journal article · DOI 10.1021/jm000226cSelective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970537w2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Rosowsky A, Papoulis AT, Queener SF.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970399aNonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970055kSynthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.
Gangjee A, Vasudevan A, Queener SF.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960734f2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A, Vasudevan A, Queener SF, Kisliuk RL.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm950786pNew drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Queener SF.
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Marlowe CK, Selassie CD, Santi DV.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00006a016Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
So SS, Richards WG.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00095a016On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Selassie CD, Li RL, Poe M, Hansch C.
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Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00128a035Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Selassie CD, Fang ZX, Li RL, Hansch C, Klein T, Langridge R, Kaufman BT.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00155a006