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Publikationer i urvalet

21 träffar

Bibliografisk träff 2019-12-09

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.

Tokay E, Güngör T, Hacıoğlu N, Önder FC, Gülhan ÜG, Tok TT, Çelik A, Ay M, Köçkar F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111937

Bibliografisk träff 2019-03-23

PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.

Güngör T, Önder FC, Tokay E, Gülhan ÜG, Hacıoğlu N, Tok TT, Çelik A, Köçkar F, Ay M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.03.035

Bibliografisk träff 2016-11-11

Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs.

Burke PJ, Wong LC, Jenkins TC, Knox RJ, Meikle IT, Stanforth SP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.11.024

Bibliografisk träff 2012-04-11

An unusually cold active nitroreductase for prodrug activations.

Çelik A, Yetiş G.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2012.04.004

Bibliografisk träff 2011-10-18

The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase.

Burke PJ, Wong LC, Jenkins TC, Knox RJ, Stanforth SP.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.10.044

Bibliografisk träff 2010-08-02

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.

Bot C, Hall BS, Bashir N, Taylor MC, Helsby NA, Wilkinson SR.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00800-10

Bibliografisk träff 2010-05-03

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Sokolova AY, Wyllie S, Patterson S, Oza SL, Read KD, Fairlamb AH.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00332-10

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2007-07-06

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.

Seville S, Phillips RM, Shnyder SD, Wright CW.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.06.062

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2007-02-28

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm061062o

Bibliografisk träff 2006-07-01

Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.

Jiang Y, Han J, Yu C, Vass SO, Searle PF, Browne P, Knox RJ, Hu L.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm051246n

Bibliografisk träff 2004-06-01

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0498699

Bibliografisk träff 2003-12-01

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.

Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm030308b

Bibliografisk träff 2003-11-01

Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.

Hu L, Yu C, Jiang Y, Han J, Li Z, Browne P, Race PR, Knox RJ, Searle PF, Hyde EI.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm034133h

Bibliografisk träff 2003-06-01

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.

Hay MP, Atwell GJ, Wilson WR, Pullen SM, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0205191

Bibliografisk träff 2000-10-01

Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.

Parkinson GN, Skelly JV, Neidle S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000159m

Bibliografisk träff 1999-12-01

Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).

Hay MP, Wilson WR, Denny WA.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(99)00627-7

Bibliografisk träff 1997-04-01

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.

Friedlos F, Denny WA, Palmer BD, Springer CJ.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm960794l

Bibliografisk träff 1994-07-01

Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.

Palmer BD, Wilson WR, Atwell GJ, Schultz D, Xu XZ, Denny WA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00040a009

Bibliografisk träff 1992-08-01

Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.

Palmer BD, Wilson WR, Cliffe S, Denny WA.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00095a018