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Publikationer i urvalet

50 träffar

Bibliografisk träff 2022-07-27

Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.

Ivankin DI, Dyrkheeva NS, Zakharenko AL, Ilina ES, Zarkov TO, Reynisson J, Luzina OA, Volcho KP, Salakhutdinov NF, Lavrik OI.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.128909

Bibliografisk träff 2022-05-31

Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines.

Ogbonna EN, Paul A, Ross Terrell J, Fang Z, Chen C, Poon GMK, Boykin DW, Wilson WD.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2022.116861

Bibliografisk träff 2021-06-09

New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: Synthesis, in vitro and in vivo biological evaluation, and molecular modelling studies.

Arafa RK, Ismail MA, Wenzler T, Brun R, Paul A, Wilson WD, Alakhdar AA, Boykin DW.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113625

Bibliografisk träff 2020-09-30

Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases.

Qian K, Yan C, Su H, Dang T, Zhou B, Wang Z, Zhao X, Ivanov I, Ho MC, Zheng YG.

RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00259c

Bibliografisk träff 2019-02-01

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.

Depauw S, Lambert M, Jambon S, Paul A, Peixoto P, Nhili R, Marongiu L, Figeac M, Dassi C, Paul-Constant C, Billoré B, Kumar A, Farahat AA, Ismail MA, Mineva E, Sweat DP, Stephens CE, Boykin DW, Wilson WD, David-Cordonnier MH.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.8b01448

Bibliografisk träff 2018-10-28

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.

Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.055

Bibliografisk träff 2018-07-24

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.

Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.07.039

Bibliografisk träff 2018-03-12

Evaluation of analogues of furan-amidines as inhibitors of NQO2.

Alnabulsi S, Hussein B, Santina E, Alsalahat I, Kadirvel M, Magwaza RN, Bryce RA, Schwalbe CH, Baldwin AG, Russo I, Stratford IJ, Freeman S.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.03.025

Bibliografisk träff 2017-01-03

Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.

Zhang J, Qian K, Yan C, He M, Jassim BA, Ivanov I, Zheng YG.

Medchemcomm · research-article; journal article · DOI 10.1039/c6md00573j

Bibliografisk träff 2016-12-23

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.

Sauer B, Skinner-Adams TS, Bouchut A, Chua MJ, Pierrot C, Erdmann F, Robaa D, Schmidt M, Khalife J, Andrews KT, Sippl W.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.12.041

Bibliografisk träff 2016-03-29

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.

Scott FJ, Khalaf AI, Giordani F, Wong PE, Duffy S, Barrett M, Avery VM, Suckling CJ.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2016.03.064

Bibliografisk träff 2015-06-14

Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Berger ML, Maciejewska D, Vanden Eynde JJ, Mottamal M, Żabiński J, Kaźmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.06.012

Bibliografisk träff 2014-03-06

Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.

Yan L, Yan C, Qian K, Su H, Kofsky-Wofford SA, Lee WC, Zhao X, Ho MC, Ivanov I, Zheng YG.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401884z

Bibliografisk träff 2013-11-09

Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.

Patrick DA, Bakunov SA, Bakunova SM, Wenzler T, Brun R, Tidwell RR.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.10.050

Bibliografisk träff 2013-08-13

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.

Hu L, Patel A, Bondada L, Yang S, Wang MZ, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW.

Bioorg Med Chem · research-article; journal article · DOI 10.1016/j.bmc.2013.08.006

Bibliografisk träff 2013-06-25

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.

Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.06.033

Bibliografisk träff 2013-06-24

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm400508e

Bibliografisk träff 2012-10-08

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Sirivolu VR, Vernekar SK, Marchand C, Naumova A, Chergui A, Renaud A, Stephen AG, Chen F, Sham YY, Pommier Y, Wang Z.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm3008773

Bibliografisk träff 2012-04-26

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm300335n

Bibliografisk träff 2011-03-01

Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.

Farahat AA, Paliakov E, Kumar A, Barghash AE, Goda FE, Eisa HM, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.02.045

Bibliografisk träff 2010-12-05

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.

Ismail MA, Bialy SA, Brun R, Wenzler T, Nanjunda R, Wilson WD, Boykin DW.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2010.11.047

Bibliografisk träff 2010-05-10

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01617-09

Bibliografisk träff 2010-03-27

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.

Branowska D, Farahat AA, Kumar A, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2010.03.058

Bibliografisk träff 2010-01-28

Theoretical models of pentamidine analogs activity based on their DNA minor groove complexes.

Zołek T, Maciejewska D.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2010.01.047

Bibliografisk träff 2009-12-11

Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.

Farahat AA, Kumar A, Say M, Barghash Ael-D, Goda FE, Eisa HM, Wenzler T, Brun R, Liu Y, Mickelson L, Wilson WD, Boykin DW.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.12.011

Bibliografisk träff 2009-09-28

In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.

Gillingwater K, Kumar A, Anbazhagan M, Boykin DW, Tidwell RR, Brun R.

Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00422-09

Bibliografisk träff 2009-08-07

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Hu L, Arafa RK, Ismail MA, Patel A, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2009.07.080

Bibliografisk träff 2009-07-20

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.

Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00225-09

Bibliografisk träff 2009-03-24

Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.

Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.03.014

Bibliografisk träff 2007-12-17

The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.

Lanteri CA, Tidwell RR, Meshnick SR.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00642-07